David F. Choy, Kevin M. Hart, Lee A. Borthwick, Aarti Shikotra et al.
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n = 51), endobronchial tissue gene expression analysis revealed three major patient clusters: TH2-high, TH17-high, and TH2/17...
Emma Doran, David F. Choy, Aarti Shikotra, Claire A. Butler et al.
Severe asthma represents a major unmet clinical need. Eosinophilic inflammation persists in the airways of many patients with uncontrolled asthma, despite high-dose inhaled corticosteroid therapy. Suppressors of cytokine signalling (SOCS) are a family of molecules involved in the regulation of cytok...
Aarti Shikotra, David F. Choy, Salman Siddiqui, Greer Arthur et al.
<b>Background:</b> Understanding the pathophysiology of severe asthma is essential for the development of novel therapies. Carcinoembryonic antigen cell adhesion molecule (CEACAM) family members are expressed in healthy lung tissue, and have properties that suggest they may play a role in asthma pat...