Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Pam Factor‐Litvak et al.
Recently, epidemiologic studies of developmental neurotoxicology have been challenged to increase focus on co-exposure to multiple toxicants. Earlier reports, including our own work in Bangladesh, have demonstrated independent associations between neurobehavioral function and exposure to both arseni...
Faruque Parvez, Gail A. Wasserman, Pam Factor‐Litvak, Xinhua Liu et al.
BACKGROUND: Several reports indicate that drinking water arsenic (WAs) and manganese (WMn) are associated with children's intellectual function. Very little is known, however, about possible associations with other neurologic outcomes such as motor function. METHODS: We investigated the associations...
Brandilyn A. Peters, Megan N. Hall, Xinhua Liu, Faruque Parvez et al.
BACKGROUND: The World Health Organization estimates that > 140 million people worldwide are exposed to arsenic (As)-contaminated drinking water. As undergoes biologic methylation, which facilitates renal As elimination. In folate-deficient individuals, this process is augmented by folic acid (FA) su...
Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Pam Factor‐Litvak et al.
BACKGROUND: Arsenic (As) exposure from drinking water is associated with modest intellectual deficits in childhood. It is not known whether reducing exposure is associated with improved intelligence. OBJECTIVE: We aimed to determine whether reducing As exposure is associated with improved child inte...
Megan N. Hall, Megan M. Niedzwiecki, Xinhua Liu, Kristin N. Harper et al.
BACKGROUND: In vitro and rodent studies have shown that arsenic (As) exposure can deplete glutathione (GSH) and induce oxidative stress. GSH is the primary intracellular antioxidant; it donates an electron to reactive oxygen species, thus producing glutathione disulfide (GSSG). Cysteine (Cys) and cy...
Abu Baker Siddique, Md. Moniruzzaman, Sobur Ali, Md. Nayem Dewan et al.
Vibrio parahaemolyticus is a major foodborne pathogen responsible for significant economic losses in aquaculture and a threat to human health. Here, we explored the incidence, virulence potential, and diversity of V. parahaemolyticus isolates from aquaculture farms in Bangladesh. We examined a total...
Megan M. Niedzwiecki, Megan N. Hall, Xinhua Liu, Julie Oka et al.
Background: Several studies employing cell culture and animal models have suggested that arsenic (As) exposure induces global DNA hypomethylation. However, As has been associated with global DNA hypermethylation in human study populations. We hypothesized that this discrepancy may reflect a nonlinea...
Caitlin G. Howe, Megan M. Niedzwiecki, Megan N. Hall, Xinhua Liu et al.
Chronic exposure to inorganic arsenic (InAs) through drinking water is a major problem worldwide. InAs undergoes hepatic methylation to form mono- and dimethyl arsenical species (MMA and DMA, respectively), facilitating arsenic elimination. Both reactions are catalyzed by arsenic (+3 oxidation state...
Danella Hafeman, Habibul Ahsan, Elan D. Louis, Abu Baker Siddique et al.
OBJECTIVES: We examined the association between arsenic exposure and peripheral neuropathy in Bangladesh, where the population has been chronically exposed to arsenic in drinking water. METHODS: We conducted a cross-sectional study of 137 subjects derived from a larger cohort. Exposure measures incl...
Anne K. Bozack, Megan N. Hall, Xinhua Liu, Vesna Ilievski et al.
Background Arsenic exposure through drinking water persists in many regions. Inorganic As (InAs) is methylated to monomethyl-arsenical species (MMAs) and dimethyl-arsenical species (DMAs), facilitating urinary excretion. Arsenic methylation is dependent on one-carbon metabolism, which is influenced ...
Mohammad Abu Baker Siddique, A. K. Shakur Ahammad, Abul Bashar, Neaz A. Hasan et al.
Bangladesh is among the countries most vulnerable to climate change due to its geographical location. Climate change issues have become major concerns in aquaculture industry, particularly for fish hatchery productivity. Fish production in Bangladesh is mainly steered by the aquaculture sector, whic...
Megan M. Niedzwiecki, Xinhua Liu, Megan N. Hall, Tiffany Thomas et al.
BACKGROUND: Depletion of global 5-hydroxymethylcytosine (5-hmC) is observed in human cancers and is strongly implicated in skin cancer development. Although arsenic (As)-a class I human carcinogen linked to skin lesion and cancer risk-is known to be associated with changes in global %5-methylcytosin...
Mohammad Abu Baker Siddique, A. K. Shakur Ahammad, Balaram Mahalder, Md. Mehedi Alam et al.
The impacts of climate change (CC) on all spheres of human life are evident worldwide. Fish is the premier protein source, and its production in Bangladesh is mainly dependent on hatchery-based seed production. However, hatchery productivity is disrupted every year due to CC. This study assesses the...
Caitlin G. Howe, Xinhua Liu, Megan N. Hall, Vesna Slavkovich et al.
BACKGROUND: Exposure to inorganic arsenic is associated with numerous adverse health outcomes, with susceptibility differing by sex. Although evidence from in vitro studies suggests that arsenic alters post-translational histone modifications (PTHMs), evidence in humans is limited. OBJECTIVES: The o...
Brandilyn A. Peters, Megan N. Hall, Xinhua Liu, Vesna Slavkovich et al.
Background Arsenic (As) methylation capacity in epidemiologic studies is typically indicated by the proportions of inorganic As (%InAs), monomethylarsonic acid (%MMA), and dimethylarsinic acid (%DMA) in urine as a fraction of total urinary As. The relationship between renal function and indicators o...
Md. Abu Bakar Siddique, Musaddiqur Rahman Ovi, Tanvir Ahammed, Muhammad Abdul Baker Chowdhury et al.
Negative attitudes toward mental illness and treatment are attributed to a lack of or inaccurate mental health knowledge. We aimed to assess the current mental health knowledge and awareness among Bangladeshi university students and identified socio-demographic factors that affect them. Between Febr...
Megan M. Niedzwiecki, Xinhua Liu, Huiping Zhu, Megan N. Hall et al.
Background Inorganic arsenic (As) is methylated via one carbon metabolism (OCM) to mono- and dimethylated arsenicals (MMA and DMA), facilitating urinary excretion. Hyperhomocysteinemia (HHcys), a marker of impaired OCM, is a risk factor for As-induced skin lesions, but the influences of single nucle...
Brandilyn A. Peters, Xinhua Liu, Megan N. Hall, Vesna Ilievski et al.
Exposure to arsenic (As) in drinking water is a widespread public health problem leading to increased risk for multiple outcomes such as cancer, cardiovascular disease, and possibly renal disease; potential mechanisms include inflammation and oxidative stress. We tested the hypothesis that As exposu...
Balaram Mahalder, Mohammad Mahfujul Haque, Mohammad Abu Baker Siddique, Neaz A. Hasan et al.
). Scientific and evidence-based embryonic and larval development research on this fish species in the context of climate change is limited. This experimental study was conducted via induced breeding of stinging catfish using a conventional hatchery system, rearing the larvae in hapas placed in pond...
Mohammad Abu Baker Siddique, Balaram Mahalder, Mohammad Mahfujul Haque, Mobin Hossain Shohan et al.
Tilapia farming has expanded rapidly in Bangladesh over the years thanks to a suitable climate for aquaculture and a consistently increasing demand for the fish rich in vitamins and minerals. A clear picture regarding the future trend of tilapia production in Bangladesh is still not available, howev...