Ahlam Abuawad, Miranda J. Spratlen, Faruque Parvez, Vesna Slavkovich et al.
BACKGROUND: Water-borne arsenic (As) exposure is a global health problem. Once ingested, inorganic As (iAs) is methylated to mono-methyl (MMA) and dimethyl (DMA) arsenicals via one-carbon metabolism (OCM). People with higher relative percentage of MMA (MMA%) in urine (inefficient As methylation), ha...
Ahlam Abuawad, Jeff Goldsmith, Julie B. Herbstman, Faruque Parvez et al.
Urinary As (uAs) is a biomarker of As exposure. Urinary creatinine (uCr) or specific gravity (SG) are used to correct uAs for urine dilution. However, uCr is correlated with As methylation, whereas SG has limitations in individuals with kidney damage. We aimed to evaluate which urine dilution correc...
Ahlam Abuawad, Anne K. Bozack, Ana Navas‐Acién, Jeff Goldsmith et al.
Background: Chronic arsenic (As) exposure is a global environmental health issue. Inorganic As (InAs) undergoes methylation to monomethyl (MMAs) and dimethyl-arsenical species (DMAs); full methylation to DMAs facilitates urinary excretion and is associated with reduced risk for As-related health out...
Ahlam Abuawad, Anne K. Bozack, Ana Navas‐Acién, Jeff Goldsmith et al.
Background and Aim. Arsenic exposure is a global issue. Inorganic As (InAs) undergoes methylation to monomethyl (MMAs) and dimethyl-arsenical species (DMAs); full methylation to DMAs facilitates urinary excretion and can reduce risk of adverse health outcomes. Folate and creatine influence one-carbo...
Ahlam Abuawad, Faruque Parvez, Tariqul Islam, Joe H. Graziano et al.
BACKGROUND AND AIM: Millions of people worldwide are exposed to arsenic (As). Urinary As (uAs) is a biomarker of As exposure. Urinary creatinine (uCr), a breakdown product of creatine, is used to correct uAs for urine dilution. However, uCr levels are influenced by meat intake, muscle mass, and fact...
Ahlam Abuawad, Faruque Parvez, Tariqul Islam, Joseph H. Graziano et al.
Background. Arsenic (As) exposure remains ubiquitous affecting hundreds of millions of people worldwide. Urinary As (uAs) is an established biomarker of As exposure; urinary creatinine (uCr), a breakdown product of creatine phosphate in muscle, is excreted constantly via urine and commonly used to c...
Ahlam Abuawad, Miranda J. Spratlen, Ana Navas‐Acién, Mary V. Gamble
TPS 636: Metals and health 2, Johan Friso Foyer, Floor 1, August 28, 2019, 3:00 PM - 4:30 PM Worldwide, over 140 million individuals are exposed to arsenic (As) in drinking water above 10 μg/L, the WHO safety standard. The methylation of ingested arsenic (As) forms mono-methyl (MMA) and dimethyl (DM...
Ahlam Abuawad, Miranda J. Spratlen, Ana Navas‐Acién, Mary V. Gamble
Ingested arsenic (As) undergoes methylation generating mono-methyl (MMA) and dimethyl (DMA) arsenicals; this facilitates urinary As (uAs) elimination and may reduce As toxicity. Higher MMA% in urine has been associated with higher risk for cardiovascular disease and cancer. Decreased MMA%, however, ...