Maria Argos, Tara Kalra, Paul J. Rathouz, Yu Chen et al.
Background Millions of people worldwide are chronically exposed to arsenic through drinking water, including 35–77 million people in Bangladesh. The association between arsenic exposure and mortality rate has not been prospectively investigated by use of individual-level data. We therefore prospecti...
Norihiro Kato, CARDIo GRAMplusCD, LifeLines Cohort Study, Marie Loh et al.
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). ...
Yu Chen, Faruque Parvez, Mary V. Gamble, Tariqul Islam et al.
The contamination of groundwater by arsenic in Bangladesh is a major public health concern affecting 35-75 million people. Although it is evident that high levels (>300 microg/L) of arsenic exposure from drinking water are related to adverse health outcomes, health effects of arsenic exposure at low...
M. Feroze Ahmed, S. Ahuja, Mohammad Alauddin, Stephan J. Hug et al.
Excessive levels of arsenic in drinking water is a vast health problem in Southeast Asia. Several viable approaches to mitigation could drastically reduce arsenic exposure, but they all require periodic testing.
Brandon L. Pierce, Muhammad G. Kibriya, Tong Lin, Farzana Jasmine et al.
Arsenic contamination of drinking water is a major public health issue in many countries, increasing risk for a wide array of diseases, including cancer. There is inter-individual variation in arsenic metabolism efficiency and susceptibility to arsenic toxicity; however, the basis of this variation ...
Yu Chen, Fen Wu, Mengling Liu, Faruque Parvez et al.
BACKGROUND: Few prospective studies have evaluated the influence of arsenic methylation capacity on cardiovascular disease (CVD) risk. OBJECTIVE: We evaluated the association of arsenic exposure from drinking water and arsenic methylation capacity with CVD risk. METHOD: We conducted a case-cohort st...
Faruque Parvez, Yu Chen, Mahbub Yunus, Christopher O. Olopade et al.
RATIONALE: Exposure to arsenic through drinking water has been linked to respiratory symptoms, obstructive lung diseases, and mortality from respiratory diseases. Limited evidence for the deleterious effects on lung function exists among individuals exposed to a high dose of arsenic. OBJECTIVES: To ...
F. Parvez, Yu Chen, Paul W. Brandt‐Rauf, Vesna Slavkovich et al.
BACKGROUND AND AIMS: A prospective cohort study was conducted to evaluate the effect of arsenic (As) exposure from drinking water on respiratory symptoms using data from the Health Effects of Arsenic Exposure Longitudinal Study (HEALS), a large prospective cohort study established in Ariahazar, Bang...
Yu Chen, Fen Wu, Joseph H. Graziano, Faruque Parvez et al.
We conducted a cross-sectional study to evaluate the interrelationships between past arsenic exposure, biomarkers specific for susceptibility to arsenic exposure, and carotid intima-media thickness (cIMT) in 959 subjects from the Health Effects of Arsenic Longitudinal Study in Bangladesh. We measure...
Rick J. Jansen, Maria Argos, Tong Lin, Jiabei Li et al.
BACKGROUND: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine ...
Julia E. Heck, Emily Marcotte, Maria Argos, F. Parvez et al.
BACKGROUND: Betel quid is chewed by 600 million people worldwide and it has been linked to obesity and cardiovascular disease. The purpose of our study was to examine the prevalence and predictors of betel quid chewing in a rural area of Bangladesh, and determine its effects on body mass index (BMI)...
Emily Vogtmann, Jun Chen, Muhammad G. Kibriya, Yu Chen et al.
ABSTRACT To our knowledge, fecal microbiota collection methods have not been evaluated in low- and middle-income countries. Therefore, we evaluated five different fecal sample collection methods for technical reproducibility, stability, and accuracy within the Health Effects of Arsenic Longitudinal ...
Fen Wu, Yu Chen, Faruque Parvez, Stephanie Segers et al.
BACKGROUND: Limited data are available on smoking-related mortality in low-income countries, where both chronic disease burden and prevalence of smoking are increasing. METHODS: Using data on 20,033 individuals in the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh, we prospective...
A Mowl, Mohammad Alauddin, Md. Atiar Rahman, K. Ahmed
The effects of ethanol extract of Trigonella foenum-graecum (Fenugreek) seeds on the blood glucose levels in alloxan-induced diabetic rats at different doses (2g/kg, 1g/kg, 0.5g/kg and 0.1g/kg) were studied. The hypoglycemic effect of extract was compared with that of the standard antidiabetic drug ...
Wendy Verret, Yu Chen, Alauddin Ahmed, Tariqul Islam et al.
OBJECTIVE: We sought to determine whether supplementation of vitamin E (alpha-tocopherol), selenium (L-selenomethionine), or their combination improves arsenical skin lesions. METHODS: A 2 x 2 randomized, placebo-controlled, double-blind trial among 121 men and women chronically exposed to arsenic i...
Rachel Nolan-Kenney, Fen Wu, Jiyuan Hu, Liying Yang et al.
INTRODUCTION: Epidemiological studies that investigate alterations in the gut microbial composition associated with smoking are lacking. This study examined the composition of the gut microbiome in smokers compared with nonsmokers. AIMS AND METHODS: Stool samples were collected in a cross-sectional ...
Jieying Jiang, Mengling Liu, Faruque Parvez, Binhuan Wang et al.
BackgroundCross-sectional studies have shown associations between arsenic exposure and prevalence of high blood pressure; however, studies examining the relationship of arsenic exposure with longitudinal changes in blood pressure are lacking.MethodWe evaluated associations of arsenic exposure in rel...
Maria Argos, Faruque Parvez, Mahfuzar Rahman, Muhammad Rakibuz‐Zaman et al.
BACKGROUND: Chronic arsenic exposure through drinking water is a public health problem affecting millions of people worldwide, including at least 30 million in Bangladesh. We prospectively investigated the associations of arsenic exposure and arsenical skin lesion status with lung disease mortality ...
Brandon L. Pierce, Tara Kalra, Maria Argos, F. Parvez et al.
BACKGROUND: Body mass index (BMI) (kg/m(2)) has a U- or J-shaped relationship with all-cause mortality in Western and East Asian populations. However, this relationship is not well characterized in Bangladesh, where the BMI distribution is shifted towards lower values. METHODS: Using data on 11,445 ...
Stephanie C. Melkonian, Maria Argos, Megan N. Hall, Yu Chen et al.
BACKGROUND: We utilized data from the Health Effects of Arsenic Longitudinal Study (HEALS) in Araihazar, Bangladesh, to evaluate the association of steamed rice consumption with urinary total arsenic concentration and arsenical skin lesions in the overall study cohort (N=18,470) and in a subset with...