Osasuyi Iyasere, Edwina A. Brown, Lina Johansson, Les Huson et al.
BACKGROUND AND OBJECTIVES: In-center hemodialysis (HD) is often the default dialysis modality for older patients. Few centers use assisted peritoneal dialysis (PD), which enables treatment at home. This observational study compared quality of life (QoL) and physical function between older patients o...
JONATHAN H. SHANKS, CLAIRE M. HILL, TERENCE R. J. LAPPIN, Alexander P. Maxwell
Erythropoietin (EPO) is the main humoral stimulus of erythropoiesis. In adult mammals, the kidney releases EPO in response to hypoxic stress. Conflicting data have suggested either renal tubular or peritubular cell origins of EPO synthesis in vivo. In situ hybridization studies were performed to def...
Senjuti Saha, Chidozie D. Ojobor, Annie Si Cong Li, Erik Mackinnon et al.
Pseudomonas aeruginosa is an opportunistic pathogen that causes antibiotic-resistant infections with high mortality rates, particularly in immunocompromised individuals and cystic fibrosis patients. Due to the increasing frequency of multidrug-resistant P. aeruginosa infections, there is great need ...
R. A. O’Neill, Patrick J. Gallagher, Tricia Douglas, Julie‐Anne Little et al.
BACKGROUND: Administering anti-vascular endothelial growth factor (anti-VEGF) by intraocular injection has been shown to have a safe systemic profile. Nevertheless, incidents of acute kidney injury following anti-VEGF injection have been reported. We assessed the long-term effect of multiple intravi...
Alexander P. Maxwell, Karolina Lindén, Sharon O’Donnell, Paul Hamilton et al.
Hyperkalaemia, an elevated extracellular fluid potassium concentration, is a common electrolyte disorder and is present in 1-10% of hospitalised patients. Elevated serum potassium concentrations are usually asymptomatic but may be associated with electrocardiogram (ECG) changes. Hyperkalaemia occasi...
Richard McCrory, Gerard Gormley, Alexander P. Maxwell, Tim Dornan
INTRODUCTION: Prescribing intravenous (IV) fluid therapy is a core skill expected of qualified doctors at the point of graduation, but medical graduates often feel ill-equipped to perform this task. This lack of preparedness contributes to treatment-related patient harm. This scoping review maps the...
R. A. O’Neill, Alexander P. Maxwell, Euan Paterson, Frank Kee et al.
BACKGROUND: The retinal and cerebral microvasculature share similar embryological origins and physiological characteristics. Improved imaging technologies provide opportunistic non-invasive assessment of retinal microvascular parameters (RMPs) against cognitive outcomes. We evaluated baseline measur...
R. A. O’Neill, Alexander P. Maxwell, Frank Kee, Ian Young et al.
Abstract Background Previous studies have identified retinal microvascular features associated with renal dysfunction. Biopsies are necessary to confirm kidney microvascular damage and retinal imaging may enable evaluation of microangiopathic characteristics reflecting renal changes associated with ...
Sarah Kreps
Abstract Observers of United States (US) interventions have almost universally characterized the 1994 Haiti intervention as multilateral, a model for how international cooperation can achieve common security goals. A closer analysis of the intervention reveals that the planning and execution of the ...
Alexander A. Kist, Andrew Maxwell, Peter Gibbings
His research examined novel mechatronic methods for the measurement of CO2 using chemical transduction.
J. Smyth, David A. Savage, Alexander P. Maxwell
Clare Mc Keaveney, Joanne Reid, Claire Carswell, Ann Bonner et al.
BACKGROUND: Globally, renal healthcare practitioners provide intensive and protracted support to a highly complex multi-morbid patient population however knowledge about the impact of COVID-19 on these practitioners is extremely limited. OBJECTIVE: This study aimed to explore the experiences of COVI...
T.S. Hataley, Kim Richard Nossal
Abstract Enthusiasts of human security argue that what is needed in the post‐Cold‐War period is a foreign policy agenda that is more ‘people‐centred’ than the state‐centred focus of security policy during the Cold War period. Among the most enthusiastic proponents of the human security paradigm in t...
Clare McKeaveney, Helen Noble, Ilaria de Barbieri, Veronica Strini et al.
BACKGROUND: Cachexia is a wasting syndrome found within a range of chronic illnesses/life-limiting conditions, however awareness and understanding of cachexia amongst renal Health Care Professionals has not been investigated. OBJECTIVES: To ascertain the awareness, understanding and treatment practi...
R. A. O’Neill, Alexander P. Maxwell, Frank Kee, Ian Young et al.
INTRODUCTION: The retina shares similar anatomical and physiological features with the brain and subtle variations in retinal microvascular parameters (RMPs) may reflect similar vascular variation in the brain. The aim of this study was to assess associations between RMPs and measures of depression ...
Senjuti Saha, Chidozie D. Ojobor, Erik Mackinnon, Olesia I. North et al.
ABSTRACT Most Pseudomonas aeruginosa strains produce bacteriocins derived from contractile or non-contractile phage tails known as R-type and F-type pyocins, respectively. These bacteriocins possess strain-specific bactericidal activity against P. aeruginosa and likely increase evolutionary fitness ...
Ciarán Kennedy, Ross Doyle, Oisin Gough, Caitríona M. McEvoy et al.
Key Points We have identified a transcriptional signature of 93 genes associated with CKD severity and progression. Protein 4.1, ezrin, radixin, moesin domain-containing protein 3 gene expression is reduced in the context of more severe kidney disease and in individuals who go on to develop progress...
Claire Tonry, Raymond M. Evans, Mark W. Ruddock, Brian Duggan et al.
AIMS: To identify clinical features and protein biomarkers associated with bladder cancer (BC) in individuals with type 2 diabetes mellitus presenting with haematuria. MATERIALS AND METHODS: Data collected from the Haematuria Biomarker (HaBio) study was used in this analysis. A matched sub-cohort of...
R. A. O’Neill, Alexander P. Maxwell, Frank Kee, Ian Young et al.
BACKGROUND: The retinal microvasculature offers unique non-invasive evaluation of systemic microvascular abnormalities. Previous studies reported associations between retinal microvascular parameters (RMPs) and diabetes. The aim of this study was to assess associations between RMPs and diabetes in a...
Jürgen Matthäus, Martin Shaw, Omer Bartov, Doris L. Bergen et al.
Click to increase image sizeClick to decrease image size Notes The views presented here are my own; they do not represent the opinions of the US Holocaust Memorial Museum. On the latter, see Timothy Snyder, ‘The coming age of slaughter: will global warming unleash genocide?’, The New Republic, 28 Oc...