James A Platts-Mills, Sudhir Babji, Ladaporn Bodhidatta, Jean Gratz et al.
BACKGROUND: Most studies of the causes of diarrhoea in low-income and middle-income countries have looked at severe disease in people presenting for care, and there are few estimates of pathogen-specific diarrhoea burdens in the community. METHODS: We undertook a birth cohort study with not only int...
James A Platts-Mills, Jie Liu, Elizabeth T. Rogawski McQuade, Furqan Kabir et al.
BACKGROUND: Optimum management of childhood diarrhoea in low-resource settings has been hampered by insufficient data on aetiology, burden, and associated clinical characteristics. We used quantitative diagnostic methods to reassess and refine estimates of diarrhoea aetiology from the Etiology, Risk...
Elizabeth T. Rogawski McQuade, Jie Liu, James A Platts-Mills, Furqan Kabir et al.
BACKGROUND: Enteropathogen infections in early childhood not only cause diarrhoea but contribute to poor growth. We used molecular diagnostics to assess whether particular enteropathogens were associated with linear growth across seven low-resource settings. METHODS: We used quantitative PCR to dete...
Elizabeth T. Rogawski McQuade, Luther A. Bartelt, James A Platts-Mills, Jessica C. Seidman et al.
BACKGROUND.: Giardia are among the most common enteropathogens detected in children in low-resource settings. We describe here the epidemiology of infection with Giardia in the first 2 years of life in the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Conseq...
Eric R. Houpt, Jean Gratz, Margaret Kosek, Anita K. M. Zaidi et al.
A central hypothesis of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study is that enteropathogens contribute to growth faltering. To examine this question, the MAL-ED network of investigators set ou...
Elizabeth T. Rogawski McQuade, Richard L. Guerrant, Alexandre Havt, Ila F.N. Lima et al.
BACKGROUND: Enteroaggregative E. coli (EAEC) have been associated with mildly inflammatory diarrhea in outbreaks and in travelers and have been increasingly recognized as enteric pathogens in young children with and without overt diarrhea. We examined the risk factors for EAEC infections and their a...
Poonum Korpe, Cristian Valencia, Rashidul Haque, Mustafa Mahfuz et al.
Background: Cryptosporidium species are enteric protozoa that cause significant morbidity and mortality in children worldwide. We characterized the epidemiology of Cryptosporidium in children from 8 resource-limited sites in Africa, Asia, and South America. Methods: Children were enrolled within 17 ...
Md. Ahshanul Haque, James A Platts-Mills, Estomih Mduma, Ladaporn Bodhidatta et al.
Campylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to Campylobacter jejuni/coli. The aim of this study was to assess the association between both...
Aldo Â. M. Lima, Alberto M. Soares, José Q.S. Filho, Alexandre Havt et al.
OBJECTIVE: We evaluated the impact of subclinical enteroaggregative Escherichia coli (EAEC) infection alone and in combination with other pathogens in the first 6 months of life on child growth. METHODS: Nondiarrheal samples from 1684 children across 8 Multisite Birth Cohort Study, Malnutrition and ...
Josyf C. Mychaleckyj, Alexandre Havt, Uma Nayak, Relana Pinkerton et al.
Despite its population, geographic size, and emerging economic importance, disproportionately little genome-scale research exists into genetic factors that predispose Brazilians to disease, or the population genetics of risk. After identification of suitable proxy populations and careful analysis of...
Aldo Â. M. Lima, Pedro H.Q.S. Medeiros, Alexandre Havt
PURPOSE OF REVIEW: The current review is to update the results on epidemiology, pathobiology, and genes related to virulence, clinical presentation, molecular diagnosis, antimicrobial resistance, and extraintestinal infection of enteroaggregative Escherichia coli (EAEC). RECENT FINDINGS: EAEC subcli...
Elizabeth T. Rogawski McQuade, Jie Liu, Mustafa Mahfuz, Alexandre Havt et al.
BACKGROUND: Shigellosis is a leading cause of diarrhoea in children globally. We aimed to assess the burden of specific Shigella species and Shigella flexneri serotypes, characterise their clinical syndromes and natural immunity, and evaluate their relevance as causes of diarrhoea and linear growth ...
Elizabeth T. Rogawski McQuade, Jie Liu, Mustafa Mahfuz, Alexandre Havt et al.
Aldo Â. M. Lima, Virginia L. S. C. Urtiga, Samilly Albuquerque Ribeiro, José Q.S. Filho et al.
ABSTRACT Introduction Enteroaggregative Escherichia coli (EAEC) is a major enteric pathogen in low-resource settings and can infect children with or without causing diarrhea. However, limited data exists on the impact of subclinical EAEC infections, particularly when co-detected with other pathogens...