Marc Monot, Nadine Honoré, Thierry Garnier, Nora Zidane et al.
Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6x coverage), and Il...
Ali Khamesipour, Sima Rafati, Noushin Davoudi, Fereidoun Maboudi et al.
A vaccine against different forms of leishmaniasis should be feasible considering the wealth of information on genetics and biology of the parasite, clinical and experimental immunology of leishmaniasis, and the availability of vaccines that can protect experimental animals against challenge with di...
Paul M. Kaye, Greg Matlashewski, Sakshi Mohan, Epke A. Le Rutte et al.
Leishmania infections are global, occurring in 98 countries and all World Health Organization (WHO) regions with 600 million to 1 billion people at risk of infection. Visceral leishmaniasis is associated with almost 20,000 reported deaths annually, with children under 5 years of age being at the gre...
Jan Bonhoeffer, Egeruan B. Imoukhuede, Grace M. Aldrovandi, Novilia Sjafri Bachtiar et al.
This document is intended as a guide to the protocol development for trials of prophylactic vaccines. The template may serve phases I-IV clinical trials protocol development to include safety relevant information as required by the regulatory authorities and as deemed useful by the investigators. Th...