Molly L. Kile, E. Andrés Houseman, Andrea Baccarelli, Quazi Quamruzzaman et al.
Prenatal arsenic exposure is associated with increased risk of disease in adulthood. This has led to considerable interest in arsenic's ability to disrupt fetal programming. Many studies report that arsenic exposure alters DNA methylation in whole blood but these studies did not adjust for cell mixt...
Molly L. Kile, Andrea Baccarelli, Elaine Hoffman, Letizia Tarantini et al.
BACKGROUND: Arsenic is an epigenetic toxicant and could influence fetal developmental programming. OBJECTIVES: We evaluated the association between arsenic exposure and DNA methylation in maternal and umbilical cord leukocytes. METHODS: Drinking-water and urine samples were collected when women were...
Molly L. Kile, Andrea Baccarelli, Letizia Tarantini, Elaine Hoffman et al.
The inheritance of DNA methylation patterns is a popular theory to explain the influence of parental genetic and environmental factors on the phenotype of their offspring but few studies have examined this relationship in humans. Using 120 paired maternal-umbilical cord blood samples randomly select...
Andrés Cárdenas, E. Andrés Houseman, Andrea Baccarelli, Quazi Quamruzzaman et al.
Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n = 37), umbi...
Mohammad L. Rahman, Molly L. Kile, Ema Rodrigues, Linda Valeri et al.
Background: Preterm birth is a disease of multifactorial etiologies that has environmental, social, and maternal health components. In Bangladesh, environmental arsenic exposure, child marriage, and low maternal weight gain during pregnancy are highly prevalent. These factors are often studied indiv...
Wei Jie Seow, Wen‐Chi Pan, Molly L. Kile, Andrea Baccarelli et al.
BACKGROUND: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions. OBJECTIVE: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time. METHODS: A follow-up study of 5...
Mohammad L. Rahman, Linda Valeri, Molly L. Kile, Maitreyi Mazumdar et al.
Background Shortening of gestation and intrauterine growth restriction (IUGR) are the two main determinants of birthweight. Low birthweight has been linked with prenatal arsenic exposure, but the causal relation between arsenic and birthweight is not well understood.. Objectives We applied a quantil...
Wei Jie Seow, Molly L. Kile, Andrea Baccarelli, Wen‐Chi Pan et al.
Studies have found an association between aberrant DNA methylation and arsenic-induced skin lesions. However, little is known about DNA methylation changes over time in people who develop arsenic-induced skin lesions. We sought to investigate epigenome-wide changes of DNA methylation in people who d...
Mohammad L. Rahman, Liming Liang, Linda Valeri, Li Su et al.
Altered expression of microRNAs (miRNAs) is implicated in fetal growth. However, the mechanisms by which placenta-derived miRNAs regulate birthweight are not well understood. In Phase 1, we compared the expression of 754 miRNAs in the placenta of mothers from two extreme birthweight groups (0.8-2.2 ...
Jannah Tauheed, Marco Sánchez-Guerra, Jane Lee, Ligi Paul et al.
Arsenic exposure may contribute to disease risk in humans through alterations in the epigenome. Previous studies reported that arsenic exposure is associated with changes in plasma histone concentrations. Posttranslational histone modifications have been found to differ between the brain tissue of h...
Wei Jie Seow, Wen‐Chi Pan, Molly L. Kile, Tong Lin et al.
BACKGROUND: Single-nucleotide polymorphisms (SNPs) in inflammation, one-carbon metabolism, and skin cancer genes might influence susceptibility to arsenic-induced skin lesions. METHODS: A case-control study was conducted in Pabna, Bangladesh (2001-2003), and the drinking-water arsenic concentration ...
Mohammad L. Rahman, Liming Liang, Linda Valeri, Li Su et al.
Altered expression of microRNAs (miRNAs) is implicated in fetal growth. However, the mechanisms by which placenta-derived miRNAs regulate birthweight are not well understood. In Phase 1, we compared the expression of 754 miRNAs in the placenta from two extreme birthweight groups (0.8–2.2 kg vs. 3.3–...
Mohammad Sayedur Rahman, Russ Hauser, Liming Liang, Andrea Baccarelli et al.
Introduction How in-utero exposure deregulates the regulatory function of placenta and impacts fetal growth and development is unclear. One mode of alteration may be through aberrant expression of microRNA (miRNA) in placenta. Our aim was to investigate the associations between miRNA expression prof...
Andrés Cárdenas, E. Andrés Houseman, Andrea Baccarelli, Quazi Quamruzzaman et al.
Background: There is increasing evidence that indoor air pollution exposure during pregnancy is a risk factor for poor birth outcomes, immunological disruption and low cognitive performance. Chemicals present in cookstove emissions have the ability to cross the placental barrier exposing the develop...
Wei Jie Seow, Wen‐Chi Pan, Molly L. Kile, Andrea Baccarelli et al.
Background: Chronic arsenic exposure is associated with skin lesions but the role of genetic susceptibility remains unclear. Aims: To investigate association between single nucleotide polymorphisms (SNPs) in inflammation, one-carbon metabolism and skin cancer genes and skin lesions. Methods: A case-...