Md Soriful Islam, Andrea Ciavattini, Felice Petraglia, Mario Castellucci et al.
BACKGROUND: Uterine leiomyoma (also known as fibroid or myoma) is the most common benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can produce serious clinical symptoms, including excessive uterine bleeding, pelvic pain or pressure, infertility and pregnancy...
Olga Protic, Paolo Toti, Md Soriful Islam, Rossella Occhini et al.
Uterine leiomyomas are benign tumors in the smooth muscle layer of the uterus. The most common histological type is the "usual leiomyoma", characterized by overexpression of ECM proteins, whereas the "cellular type" has higher cellular content. Our objective is to investigate the involvement of infl...
Md Soriful Islam, William H. Catherino, Olga Protic, Milijana Janjusevic et al.
CONTEXT: Uterine leiomyomas are highly prevalent benign tumors of premenopausal women and the most common indication for hysterectomy. However, the exact etiology of this tumor is not fully understood. OBJECTIVE: The objective of the study was to evaluate the role of activin-A and myostatin and thei...
Md Soriful Islam, Most Mauluda Akhtar, Andrea Ciavattini, Stefano Raffaele Giannubilo et al.
Uterine leiomyomas (fibroids, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70-80% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pressure on the bladder, misc...
Md Soriful Islam, Stefania Greco, Milijana Janjusevic, Andrea Ciavattini et al.
Growth factors are relatively small and stable, secreted or membrane-bound polypeptide ligands, which play an important role in proliferation, differentiation, angiogenesis, survival, inflammation, and tissue repair, or fibrosis. They exert multiple effects through the activation of signal transduct...
Md Soriful Islam, Francesca Giampieri, Milijana Janjusevic, Massimiliano Gasparrini et al.
// Md Soriful Islam 1, 2, * , Francesca Giampieri 3, * , Milijana Janjusevic 1 , Massimiliano Gasparrini 3 , Tamara Y. Forbes-Hernandez 3 , Luca Mazzoni 3 , Stefania Greco 1 , Stefano Raffaele Giannubilo 3 , Andrea Ciavattini 3 , Bruno Mezzetti 4 , Franco Capocasa 4 , Mario Castellucci 1 , Maurizio ...
Olga Protic, Md Soriful Islam, Stefania Greco, Stefano Raffaele Giannubilo et al.
Abstract The growth factor activin A belongs to the transforming growth factor-β superfamily and was initially isolated as an inducer of follicle-stimulating hormone secretion. Activin A was later found to play roles in cell proliferation, differentiation, apoptosis, and metabolism. More recently, a...
Francesca Giampieri, Md Soriful Islam, Stefania Greco, Massimiliano Gasparrini et al.
Uterine leiom yomas are benign tumors highly prevalent in reproductive women. In thecurrent study, initially, we aimed to screen five different strawberry cultivars (Alba, Clery, Portola, Tecla, and Romina) to identify efficient cultivars in terms of phytochemical characterization and biological pro...
Md Soriful Islam, Clara Castellucci, Rosamaria Fiorini, Stefania Greco et al.
Uterine leiomyomas (fibroids or myomas) are the most common benign tumors of premenopausal women and new medical treatments are needed. This study aimed to determine the effects of omega-3 fatty acids on the lipid profile, membrane architecture and gene expression patterns of extracellular matrix co...
Md Soriful Islam, Olga Protic, Andrea Ciavattini, Stefano Raffaele Giannubilo et al.
Objective To determine the effect of tranilast (an antiallergic drug known to suppress fibrosis or to stabilize mast cells) on extracellular matrix production in human leiomyoma and myometrial cells. Design Laboratory study. Setting University-affiliated laboratory. Patient(s) Seven premenopausal wo...
Milijana Janjusevic, Stefania Greco, Md Soriful Islam, Clara Castellucci et al.
Objective To investigate the presence of Raf kinase inhibitor protein (RKIP) in human myometrium and leiomyoma as well as to determine the effect of locostatin (RKIP inhibitor) on extracellular matrix (ECM) production, proliferation, and migration in human myometrial and leiomyoma cells. Design Labo...