Soumen Chakraborty, Asish K. Mukhopadhyay, Rupak K. Bhadra, Amar N. Ghosh et al.
The virulence of a pathogen is dependent on a discrete set of genetic determinants and their well-regulated expression. The ctxAB and tcpA genes are known to play a cardinal role in maintaining virulence in Vibrio cholerae, and these genes are believed to be exclusively associated with clinical stra...
Santanu Chattopadhyay, Rajashree Patra, T. Ramamurthy, Abhijit Chowdhury et al.
We developed and evaluated a simple, novel multiplex PCR assay for rapid detection of Helicobacter pylori infection and for the determination of vacA and cagA genotypes directly from gastric biopsy specimens. This assay did not require culturing of strains or extraction of DNA from biopsy samples. T...
Shamsun Nahar, Asish K. Mukhopadhyay, Rasel Khan, Mian Mashhud Ahmad et al.
Antimicrobial susceptibility of 120 Helicobacter pylori isolates to metronidazole, tetracycline, clarithromycin, and amoxicillin was determined, and 77.5, 15, 10, and 6.6% of the isolates, respectively, were resistant. Only rdxA inactivation and both rdxA and frxA inactivation were responsible for m...
Simanti Datta, Santanu Chattopadhyay, Rajashree Patra, Ronita De et al.
BACKGROUND: Helicobacter pylori infection is very common in India, as in other developing countries, but few data exist on the susceptibility of H. pylori to antimicrobial agents commonly used for eradication here. AIM: To determine the antimicrobial susceptibility of H. pylori strains from Kolkata,...
Rupa Chakraborty, Sutapa Sinha, Asish K. Mukhopadhyay, Masahiro Asakura et al.
Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks avail...
Santanu Chattopadhyay, Simanti Datta, Abhijit Chowdhury, Sujit Chowdhury et al.
We compared putative molecular markers of virulence (vacA, cagA, and iceA) of Helicobacter pylori strains isolated from 52 adult duodenal ulcer patients from West Bengal, India, with those of H. pylori strains isolated from 48 adult healthy volunteers from the same region. On the basis of genotyping...
Simanti Datta, Santanu Chattopadhyay, G. Balakrish Nair, Asish K. Mukhopadhyay et al.
Virulence-associated genes and neutral DNA markers of Helicobacter pylori strains from the Santhal and Oroan ethnic minorities of West Bengal, India, were studied. These people have traditionally been quite separate from other Indians and differ culturally, genetically, and linguistically from mains...
Motiur Rahman, Asish K. Mukhopadhyay, Shamsun Nahar, Simanti Datta et al.
The complex relation between the genotype of Helicobacter pylori and its association with clinical outcome is not well understood. Studies in the West have showed that strains expressing certain virulence factors (vacAs1, vacAm1, and cagA) are associated with duodenal ulcer disease. However, the H. ...
Arnab Basu, Asish K. Mukhopadhyay, Charu Sharma, Jeevan Jyot et al.
After a lapse of 33 months, Vibrio cholerae O139, the new serogroup associated with cholera, has re-emerged in Calcutta, India and has become the dominant serogroup causing cholera from September 1996. In neighbouring Bangladesh, V. cholerae O1 biotype El Tor continues to be the dominant cause of ch...
Daichi Morita, Masatomo Morita, Munirul Alam, Asish K. Mukhopadhyay et al.
Cholera continues to be a global concern, as large epidemics have occurred recently in Haiti, Yemen, and countries of sub-Saharan Africa. A single lineage of Vibrio cholerae O1 has been considered to be introduced into these regions from South Asia and to cause the spread of cholera. Using genomic e...
Asish K. Mukhopadhyay, Indira Basu, Sujit Bhattacharya, M.K. Bhattacharya et al.
The problem of antimicrobial resistance in microorganisms causing diarrheal diseases in both developed and developing countries continues to be alarming (6). Toxigenic Vibrio cholerae is the causative agent of the life-threatening disease cholera. Plasmid-encoded high-level resistance to ampicillin,...
Pengbo Liu, Makoto Ibaraki, Renuka Kapoor, Nuhu Amin et al.
Enteric fever is a severe systemic infection caused by Salmonella enterica serovar Typhi (ST) and Salmonella enterica serovar Paratyphi A (SPA). Detection of ST and SPA in wastewater can be used as a surveillance strategy to determine burden of infection and identify priority areas for water, sanita...
Sean Connor, Mirza Velagic, Xueyan Zhang, Fatema‐Tuz Johura et al.
Understanding the global burden of enterotoxigenic E. coli (ETEC) and Shigella diarrhea as well as estimating the cost effectiveness of vaccines to control these two significant pathogens have been hindered by the lack of a diagnostic test that is rapid, simple, sensitive, and can be applied to the ...
Bhaswati Sen, Basabjit Dutta, Somdatta Chatterjee, M.K. Bhattacharya et al.
Since 1996, infections caused by Vibrio parahaemolyticus have increased globally. Outbreak and/or sporadic cases of diarrhea caused by V. parahaemolyticus have been reported from India, Indonesia, Japan, Taiwan, the USA, Laos, Korea, Chile, Bangladesh, Russia, Thailand, Spain, France, and Vietnam. T...
N. A. Bhuiyan, Suraia Nusrin, M. Ansaruzzaman, Ashraful Islam et al.
New variants of Vibrio cholerae O1 have appeared in different time-frames in various endemic regions, especially in Asia and Africa. Sixty-nine strains of V. cholerae O1 isolated in Zambia between 1996 and 2004 were investigated by various genotypic techniques to determine the lineage of virulence s...