B Ogunkolade, Barbara J. Boucher, Jean M. Prahl, Stephen A. Bustin et al.
Associations have been reported between vitamin D receptor (VDR) gene polymorphisms, type 1 diabetes, insulin secretion, and the insulin resistance syndrome. As VDR polymorphisms have no known functional significance, these findings may implicate a variant of the VDR gene or a locus in linkage diseq...
G. A. Hitman, Nasima Mannan, Michael McDermott, E Aganna et al.
Sarah Finer, Mohd S. Iqbal, Robert Lowe, B Ogunkolade et al.
OBJECTIVES: Famine exposure in utero can 'programme' an individual towards type 2 diabetes and obesity in later life. We sought to identify, (1) whether Bangladeshis exposed to famine during developmental life are programmed towards diabetes and obesity, (2) whether this programming was specific to ...
W Ogunkolade, Barbara J. Boucher, Stephen A. Bustin, Jacky M. Burrin et al.
CONTEXT: Vitamin D deficiency, common in South Asians, is a risk factor for metabolic syndrome, type 2 diabetes, and ischemic heart disease. Vitamin D receptor (VDR) activation depends on activated vitamin D [1,25-dihydroxyvitamin D (1,25(OH)(2)D)] concentration, reflecting opposing actions of 25-hy...
Zahid Hassan, Viswanathan Mohan, Michael McDermott, Liaquat Ali et al.
BACKGROUND: A distinct type of pancreatitis associated with diabetes, termed fibrocalculous pancreatic diabetes (FCPD), has been reported in tropical developing countries including Bangladesh. The molecular basis for autosomal dominant hereditary pancreatitis (HP) has recently been attributed to mut...
Suraj S. Nongmaithem, Robin N. Beaumont, Akshay Dedaniya, Andrew R. Wood et al.
Size at birth is known to be influenced by various fetal and maternal factors, including genetic effects. South Asians have a high burden of low birth weight and cardiometabolic diseases, yet studies of common genetic variations underpinning these phenotypes are lacking. We generated independent, we...
Suraj S. Nongmaithem, Robin N. Beaumont, Akshay Dedaniya, Andrew R. Wood et al.
We recently reported genetic variants associated with birth weight and their effect on future cardiometabolic risk in Europeans. Despite a higher burden of low birth weight and cardiometabolic disorders, such studies are lacking in South Asians. We generated fetal and maternal genetic scores (fGS an...
Sarah Finer, Sabrina Iqbal, Christopher Mathews, B Ogunkolade et al.
Suraj S. Nongmaithem, Robin N. Beaumont, Akshay Dedaniya, Andrew R. Wood et al.
Size at birth is known to be influenced by various fetal and maternal factors including genetic effects. South Asians have a high burden of low birthweight and cardiometabolic diseases, yet studies of common genetic variations underpinning these phenotypes are lacking. We generated independent, weig...
Suraj S. Nongmaithem, Robin N. Beaumont, Akshay Dedaniya, Andrew R. Wood et al.
Size at birth is known to be influenced by various fetal and maternal factors including genetic effects. South Asians have a high burden of low birthweight and cardiometabolic diseases, yet studies of common genetic variations underpinning these phenotypes are lacking. We generated independent, weig...
Suraj S. Nongmaithem, Robin N. Beaumont, Akshay Dedaniya, Andrew R. Wood et al.
Abstract We recently reported genetic variants associated with birth weight and their effect on future cardiometabolic risk in Europeans. Despite a higher burden of low birth weight and cardiometabolic disorders, such studies are lacking in South Asians. We generated fetal and maternal genetic score...
Sarah Finer, Sabrina Iqbal, WB Ogunkolade, Christopher Mathews et al.
G. A. Hitman, W Ogunkolade, Stephen A. Bustin, J. M. Burrin et al.