Hannah E Atlas, Bakary Conteh, Md Taufiqul Islam, Khuzwayo C. Jere et al.
Abstract Background Shigella is a leading cause of acute watery diarrhea, dysentery, and diarrhea-attributed linear growth faltering, a precursor to stunting and lifelong morbidity. Several promising Shigella vaccines are in development and field efficacy trials will require a consortium of potentia...
Erika Feutz, Prasanta K. Biswas, Latif Ndeketa, Billy Ogwel et al.
Abstract Background Rigorous data management systems and planning are essential to successful research projects, especially for large, multicountry consortium studies involving partnerships across multiple institutions. Here we describe the development and implementation of data management systems a...
Ryan Dodd, Alex O Awuor, Paul F. Garcia Bardales, Farhana Khanam et al.
Abstract Background Accurate estimation of diarrhea incidence from facility-based surveillance requires estimating the population at risk and accounting for case patients who do not seek care. The Enterics for Global Health (EFGH) Shigella surveillance study will characterize population denominators...
Mohammad Tahir Yousafzai, Jennifer Cornick, Pablo Peñataro Yori, M. Jahangir Hossain et al.
Chloe Morozoff, Naveed Ahmed, Jobiba Chinkhumba, Md Taufiqul Islam et al.
Abstract Background Comparative costs of public health interventions provide valuable data for decision making. However, the availability of comprehensive and context-specific costs is often limited. The Enterics for Global Health (EFGH) Shigella surveillance study—a facility-based diarrhea surveill...
M A Yousafzai, Jennifer Cornick, Pablo Peñataro Yori, M Jahangir Hossain et al.
BACKGROUND: Shigella is a leading cause of dysentery and watery diarrhoea in low-income and middle-income countries (LMICs) with consequences beyond diarrhoea for children younger than 5 years, including environmental enteric dysfunction and linear growth impairment. We established the burden, serot...
Billy Ogwel, Farhana Khanam, Henry Badji, Mary Charles et al.
BACKGROUND: Current syndromic guidelines for diarrhea treatment miss watery Shigella cases, leading to undertreatment of children who may benefit. Incorporating fecal inflammatory biomarkers into diagnosis may improve case identification. METHODS: We conducted an ancillary analysis using samples fro...
Billy Ogwel, Alex O Awuor, Brian O. Onyando, Raphael Ochieng et al.
Abstract Although the co-occurrence of diarrhea and malnutrition is well documented, research has largely focused on the acute management of diarrheal illness. Despite its importance, longitudinal evidence characterizing post-diarrheal recovery trajectories is sparse. We sought to characterize post-...
Bakary Conteh, Sean R. Galagan, Henry Badji, Ousman Secka et al.
Abstract Globally, respiratory tract infections (RTI) are the main cause of morbidity, and in Low-middle-income countries (LMICs) RTI including pneumonia are a leading cause of morbidity and mortality in children <5 years. Diarrheal illness increases RTI risk in young children through micronutrie...
Billy Ogwel, Farhana Khanam, Henry Badji, Mary Charles et al.
Abstract Background Current syndromic guidelines for diarrhea treatment miss watery Shigella cases, leading to undertreatment of children who may benefit. Incorporating fecal inflammatory biomarkers into diagnosis may improve case identification. Methods We conducted an ancillary analysis using samp...
Donnie Mategula, Bakary Conteh, Christine J. McGrath, Erika L. Feutz et al.
Background Shigella is a leading cause of diarrheal illness in children in low- and middle-income countries, with evidence of contribution to prolonged diarrhoea, hospitalization, and impaired growth. Methods In this prospective cohort study, we analysed data from 8756 children aged 6–35 months with...
Billy Ogwel, Farhana Khanam, Henry Badji, Mary Charles et al.
BACKGROUND: Current syndromic guidelines for diarrhea treatment miss watery Shigella cases, leading to undertreatment of children who may benefit. Incorporating fecal inflammatory biomarkers into diagnosis may improve case identification. METHODS: We conducted an ancillary analysis using samples fro...
Anya Lewin, Naveed Ahmed, Doh Sanogo, Musa Jallow et al.
Olívia Lang Schultes, Aneeta Hotwani, Patricia B. Pavlinac, M Jahangir Hossain et al.
BACKGROUND: Shigella vaccine development is a critical priority due to high burden and long-term outcomes among children. Choosing a clinical efficacy endpoint for Shigella vaccine trials requires comparing existing diarrhea severity definitions among children with Shigella. METHODS: Six- to 35-mont...
Olívia Lang Schultes, Aneeta Hotwani, Patricia B. Pavlinac, M. Jahangir Hossain et al.
Abstract Background Shigella has high global burden and serious long-term outcomes among young children. Increasing antibiotic resistance makes Shigella vaccine development a critical priority. Choosing the optimal clinical efficacy endpoint for Shigella vaccine trials requires comparing existing di...