Anette Stauch, Ram Rup Sarkar, Albert Picado, Bart Ostyn et al.
BACKGROUND: In the Indian subcontinent, about 200 million people are at risk of developing visceral leishmaniasis (VL). In 2005, the governments of India, Nepal and Bangladesh started the first regional VL elimination program with the aim to reduce the annual incidence to less than 1 per 10,000 by 2...
Rupkatha Mukhopadhyay, Sandip Mukherjee, Budhaditya Mukherjee, Kshudiram Naskar et al.
Recent clinical isolates of Leishmania donovani from the hyperendemic zone of Bihar were characterised in vitro in terms of their sensitivity towards sodium stibogluconate in a macrophage culture system. The resulting half maximal effective concentration (EC(50)) values were compared with those of k...
Bart Ostyn, Veerle Vanlerberghe, Albert Picado, Diwakar Singh Dinesh et al.
Visceral leishmaniasis (VL) is a deadly vector-borne disease that causes an estimated 500 000 new cases a year. In India, Nepal and Bangladesh, VL is caused by Leishmania donovani, which is transmitted from man to man by the sandfly Phlebotomus argentipes. In 2005, these three countries signed a mem...
Diwakar Singh Dinesh, Pradeep Das, Albert Picado, Clive R. Davies et al.
OBJECTIVE: To determine whether the use of long-lasting insecticidal nets (LLINS) at household level are effective in reducing the abundance of Phlebotomus argentipes, vector of anthroponotic visceral leishmaniasis in India, Nepal and Bangladesh. METHODS: The impact of two long-lasting nets (Olyset ...
Anette Stauch, Hans-Peter Duerr, Albert Picado, Bart Ostyn et al.
The elimination of infectious diseases requires reducing transmission below a certain threshold. The Visceral Leishmaniasis (VL) Elimination Initiative in Southeast Asia aims to reduce the annual VL incidence rate below 1 case per 10,000 inhabitants in endemic areas by 2015 via a combination of case...
Basudha Khanal, Suman Rijal, Bart Ostyn, Albert Picado et al.
Visceral leishmaniasis (VL) is an important vector-borne disease caused by Leishmania donovani in the Indian subcontinent. The actual incidence and role of asymptomatic infections in the region are not well known. We used the direct agglutination test (DAT) and the rK39 ELISA as L. donovani infectio...
Veerle Vanlerberghe, Shri Prakash Singh, IS Paudel, Bart Ostyn et al.
Objective To document ownership and use of bednets with its determinants in the visceral leishmaniasis (VL)-endemic region where mainly non-insecticide impregnated nets are available through commercial channels, and bednets are being considered as a leishmaniasis vector control measure. Methods In A...
Albert Picado, Bart Ostyn, Suman Rijal, Shyam Sundar et al.
In a recent paper, Nagpal et al. Visceral leishmaniasis (VL), also known as kala-azar, is one of the major NTDs and does not escape this problem. Transmission is vector-borne and the Indian subcontinent is the region reporting most of the VL cases worldwide. In this region, the main causative specie...
Hideo Imamura, Tim Downing, Frederik Van den Broeck, Mandy Sanders et al.
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 - SNP detection procedure using the COCALL algorithm Appendix 2 - Somy, CNV, indel and episome detection Data availability References Decision letter Author response Article...