Samuel A.J. Trammell, Mark S. Schmidt, Benjamin J. Weidemann, Philip Redpath et al.
Abstract Nicotinamide riboside (NR) is in wide use as an NAD + precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD + metabolism in humans. We report that human blood NAD + can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one indiv...
Charles Brenner, Benjamin J. Weidemann, Samuel A.J. Trammell, Joshua J. Coon et al.
Caged mice represent an attractive model system with which to dissect the mechanistic basis for dietary and activity interventions because one can control for food amounts, dietary compositions, supplementation, and exercise in addition to genotype. Here we report that oral nicotinamide riboside (NR...