Leonor Gama-Norton, Eva Ferrando, Cristina Ruiz‐Herguido, Zhenyi Liu et al.
Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta-gonad-mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on Dll4 and the haemogenic endothelium/HSC on Jag1-mediated Notch1 signalling. How Notch1 dis...
Jordi Guiu, Dylan J. M. Bergen, Emma de Pater, Abul Bashar Mir Md. Khademul Islam et al.
Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements controlling de novo HSC generation are still unknown. Here, we identify putative direct Notch targets in the aorta-gonad-mesonephros (AGM) embryonic ...
Jordi Guiu, Dylan J. M. Bergen, Emma de Pater, Abul B.M.M.K. Islam et al.
generation and both lineages share a common endothelial progenitor (Zovein et al., 2008;Chen et al., 2009).The process by which an HSC precursor with endothelial characteristic acquires the hematopoietic identity is known as endothelial to hematopoietic transition.HSCs develop within specific cell c...
Leonor Gama-Norton, Jordi Guiu, Abul Bashar Mir Md. Khademul Islam, Cristina Ruiz‐Herguido et al.