Cynthia Bin Eng Chee, Kyi-Win KhinMar, Li-H. Sng, Roland Jureen et al.
Multidrug-resistant tuberculosis (MDR-TB) is a major public health challe, with an estimated 480 000 new cases emerging globally each year [1]. Treatment success rates using the 20-month conventional World Health Organization (WHO) regimen have been low, being about 52% in 2013 [1]. Observational...
Cynthia Bin-Eng Chee, Kyi Win KhinMar, Jeffery Cutter, Yee Tang Wang
The global emergence of multidrugresistant (MDR) tuberculosis (TB) and extensively drug-resistant (XDR)-TB threatens to derail the efforts of TB control programmes worldwide. From 2000 to 2010, 161 pulmonary MDR-TB cases (including six XDR-TB cases) were reported in Singapore, and of these, 80% occu...
Cynthia Bin Eng Chee, David S.C. Hui
Acute respiratory infections such as influenza and community-acquired pneumonia (CAP) are leading causes of hospitalization with significant morbidity and mortality. Tuberculosis (TB) is one of the top 10 global causes of death and the leading cause from a single infectious agent. As part of Respiro...
Cynthia Bin Eng Chee, Kyi Win KhinMar, Li Hwei Sng, Roland Jureen et al.
In May 2016, the WHO recommended a 9-12 month MDR-TB treatment regimen for pulmonary MDR-TB patients without confirmed resistance to a medicine in this regimen (excluding isoniazid resistance). The majority of MDR pulmonary TB (PTB) cases in Singapore originate from South-east Asian countries where ...