Cathryn M. Lewis, Douglas F. Levinson, Lesley H. Wise, Lynn E. DeLisi et al.
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to da...
Andréa Cornwall, Vera Schattan P. Coelho
* Foreword - John Gaventa * 1. Spaces for Change? The Politics of Participation in New Democratic Arenas - Andrea Cornwall and Vera Schattan P. Coelho * Part I: The Challenge of Inclusion ** 2. Brazilian Health Councils: including the excluded? - Vera Schattan P. Coelho ** 3. Spaces for participatio...
David J. Williams, Mohd Abul Faiz, Bernadette Abela-Ridder, Stuart Ainsworth et al.
In one of his final essays, statesman and former United Nations secretary general Kofi Annan said, ‘Snakebite is the most important tropical disease you’ve never heard of’ [1]. Mr. Annan firmly believed that victims of snakebite envenoming should be recognised and afforded greater efforts at improve...
Nicola Ragge, Alison G. M. Brown, Charlotte M. Poloschek, Birgit Lorenz et al.
Major malformations of the human eye, including microphthalmia and anophthalmia, are examples of phenotypes that recur in families yet often show no clear Mendelian inheritance pattern. Defining loci by mapping is therefore rarely feasible. Using a candidate-gene approach, we have identified heteroz...
Mandy Ng, Douglas F. Levinson, Stephen V. Faraone, Brian K. Suarez et al.
A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within ea...
Nicos Karasavvas, Erik Billings, Mangala Rao, Constance Williams et al.
The Thai Phase III clinical trial (RV144) showed modest efficacy in preventing HIV-1 acquisition. Plasma collected from HIV-1-uninfected trial participants completing all injections with ALVAC-HIV (vCP1521) prime and AIDSVAX B/E boost were tested for antibody responses against HIV-1 gp120 envelope (...
P Maxwell, Ryan S. Gallagher, Angela Seaton, Catherine Wilson et al.
Hypoxic cancer cells are resistant to treatment, leading to the selection of cells with a more malignant phenotype. The expression of interleukin-8 (IL-8) plays an important role in the tumorigenesis and metastasis of solid tumors including prostate cancer. Recently, we detected elevated expression ...
V. Spike Peterson
Click to increase image sizeClick to decrease image size Acknowledgments I am grateful to Georgina Waylen for her generosity in sharing prepublication work with me; and to Drucilla Barker, Jen Cohen, Deb Figart, Ellen Mutari, Julie Nelson, Paulette Olsen and Ara Wilson for conference discussions reg...
Dieter B. Wildenauer, Sibylle G. Schwab, Margot Albus, Joachim Hallmayer et al.
In response to reported schizophrenia linkage findings on chromosomes 3, 6 and 8, fourteen research groups genotyped 14 microsatellite markers in an unbiased, collaborative (New) sample of 403-567 informative pedigrees per marker, and in the Original sample which produced each finding (the Johns Hop...
Michael Lawton, Yoav Ben‐Shlomo, Margaret May, Fahd Baig et al.
Objectives To use a data-driven approach to determine the existence and natural history of subtypes of Parkinson’s disease (PD) using two large independent cohorts of patients newly diagnosed with this condition. Methods 1601 and 944 patients with idiopathic PD, from Tracking Parkinson’s and Discove...
Eike Steinig, Sebastián Duchêne, D. Ashley Robinson, Stefan Monecke et al.
The Bengal Bay clone (ST772) is a community-associated and multidrug-resistant Staphylococcus aureus lineage first isolated from Bangladesh and India in 2004. In this study, we showed that the Bengal Bay clone emerged from a virulent progenitor circulating on the Indian subcontinent. Its subsequent ...
Ruth Pearson
Abstract Though there is now a great deal of attention to the question of women workers and Corporate Social Responsibility (csr), a more far reaching analysis, which is informed by feminist economics approaches, stresses the importance of the gendered nature of the institutional context in which va...
Masayuki Teramoto, Marissa B Reitsma, Yohannes Abate, Abdallah H A Abd Al Magied et al.
BACKGROUND: Smoking is the leading behavioural risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking prevalence has slowed in recent years for many countries, and although st...
Francesco D’Eugenio, Alex J. Cameron, Jan Scholtz, Stefano Carniani et al.
Abstract We present the third data release of the JWST Advanced Deep Extragalactic Survey (JADES), providing both imaging and spectroscopy in the two GOODS fields. Spectroscopy consists of medium-depth and deep NIRSpec/microshutter assembly spectra of 4000 targets, covering the spectral range 0.6–5....
Rachel Bezanson, Ivo Labbé, Katherine E. Whitaker, Joel Leja et al.
Abstract In this paper we describe the survey design for the Ultradeep NIRSpec and NIRCam Observations before the Epoch of Reionization (UNCOVER) Cycle 1 JWST Treasury program, which executed its early imaging component in 2022 November. The UNCOVER survey includes ultradeep (∼29–30AB) imaging of ∼4...