Giovanni Battista Migliori, Simon Tiberi, Alimuddin Zumla, Eskild Petersen et al.
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Glob...
Seif Al Abri, Tereza Kasaeva, Giovanni Battista Migliori, Delia Goletti et al.
AIM: The purpose of this viewpoint is to summarize the advantages and constraints of the tools and strategies available for reducing the annual incidence of tuberculosis (TB) by implementing the World Health Organization (WHO) End TB Strategy and the linked WHO TB Elimination Framework, with special...
Carole Chedid, Eka Kokhreidze, Nestani Tukvadze, Sayera Banu et al.
ObjectivesTuberculosis (TB) is the leading infectious cause of death in the world. Cheaper and more accessible TB treatment monitoring methods are needed. Here, we evaluated white blood cell (WBC) absolute counts, lymphocyte, and monocyte proportions during TB treatment, and characterized their asso...
Rim Bayaa, Mame Diarra Ndiaye, Carole Chedid, Eka Kokhreidze et al.
There is a crucial need for non-sputum-based TB tests. Here, we evaluate the performance of RISK6, a human-blood transcriptomic signature, for TB screening, triage and treatment monitoring. RISK6 performance was also compared to that of two IGRAs: one based on RD1 antigens (QuantiFERON-TB Gold Plus,...
Carole Chedid, Eka Kokhreidze, Nestani Tukvadze, Sayera Banu et al.
Background Tuberculosis (TB) is a leading infectious cause of death. To improve treatment efficacy, quicker monitoring methods are needed. The objective of this study was to monitor the response to a heparin-binding hemagglutinin (HBHA) interferon- γ (IFN- γ ) release assay (IGRA) and QuantiFERON-TB...
Giovanni Battista Migliori, Pei Min Thong, Jan‐Willem C. Alffenaar, Justin T. Denholm et al.
The objective of this study was to describe country-specific lockdown measures and tuberculosis indicators collected during the first year of the COVID-19 pandemic. Data on lockdown/social restrictions (compulsory face masks and hand hygiene; international and local travel restrictions; restrictions...
Eskild Petersen, Seif Al-Abri, Jeremiah Chakaya, Delia Goletti et al.
The World Health Organization (WHO) and STOP TB Partnership theme for World TB Day 24th March, 2022 is “Invest to End TB. Save Lives” (WHO, 2022a). Global political and scientific attention continues to be focussed on the Coronavirus disease (COVID-19) pandemic. There have been over 416 million case...
Carole Chedid, Thibault Andrieu, Eka Kokhreidze, Nestani Tukvadze et al.
Tuberculosis (TB) is a difficult-to-treat infection because of multidrug regimen requirements based on drug susceptibility profiles and treatment observance issues. TB cure is defined by mycobacterial sterilization, technically complex to systematically assess. We hypothesized that microbiological o...
Claudia Sala, Andrej Benjak, Delia Goletti, Sayera Banu et al.
The impact of tuberculosis and of anti-tuberculosis therapy on composition and modification of human lung microbiota has been the object of several investigations. However, no clear outcome has been presented so far and the relationship between M. tuberculosis pulmonary infection and the resident lu...
Simon Tiberi, Giovanni Battista Migliori, Jeremiah Chakaya, Tereza Kaesava et al.
World TB Day falls on March 24th each year, and it commemorates the day in 1882 when Dr Robert Koch announced that he had discovered the microbial cause of tuberculosis, Mycobacterium tuberculosis (WHO, 2020aWHO World tuberculosis day.2020https://www.who.int/news-room/events/detail/2020/03/24/defaul...
Eskild Petersen, David S.C. Hui, Jean B. Nachega, Francine Ntoumi et al.
When Johnson & Johnson (J&J) developed the new tuberculosis (TB) drug bedaquiline (Sirturo) [[1]TB Alliance-our pipeline. Bedaquiline. https://www.tballiance.org/portfolio/compound/bedaquiline - accessed 3 April, 2023Google Scholar], it was one the few new drugs to have been conditionally approved b...
Carole Chedid, Thibault Andrieu, Eka Kokhreidze, Nestani Tukvadze et al.
Abstract Tuberculosis (TB) is a difficult-to-treat infection because of multidrug regimen requirements based on drug susceptibility profiles and treatment observance issues. TB cure is defined by mycobacterial sterilization, technically complex to systematically assess. We hypothesized that microbio...