M. John Albert, Abu Syed Golam Faruque, Shah M. Faruque, R. Bradley Sack et al.
The International Centre for Diarrhoeal Disease Research, Bangladesh, is a major center for research into diarrheal diseases. The center treats more than 100,000 patients a year. To obtain useful information representative of all patients, a surveillance system in which a 4% systematic sample of all...
Shafiqul Alam Sarker, Thomas Casswall, Dilip Mahalanabis, NUR H. ALAM et al.
BACKGROUND: Oral ingestion of immunoglobulins in humans has been shown to be effective as prophylaxis against enteric infections. However, its therapeutic effect in children with infectious diarrhea has hitherto not been proven. We treated children with rotavirus diarrhea with immunoglobulins extrac...
Roy Sk, R.H. Behrens, Rukhsana Haider, S. M. Akramuzzaman et al.
Zinc has been shown to enhance intestinal mucosal repair in patients suffering from acrodermatitis enteropathica; but the impact on mucosal integrity during acute (AD) or persistent (PD) diarrhoea is unknown. One hundred eleven children with AD and 190 with PD aged between 3 and 24 months received, ...
Dilip Mahalanabis, A. B. Choudhuri, N. Bagchi, A. K. Bhattacharya et al.
A field trial of oral electrolyte solutions for the treatment of cholera was conducted in India among war refugees from Bangladesh during the summer of 1971. The oral solution used combined sodium bicarbonate chloride and glucose prepackaged for mixing with water in the field. Potassium citrate or o...
Dilip Mahalanabis, Madhurima Lahiri, Dilip Kumar Paul, Susham Gupta et al.
Background Acute lower respiratory infection (ALRI) is a leading cause of childhood death. Zinc supplementation prevents ALRI. Vitamin A supplementation reduces childhood mortality, but its benefit concerning ALRI-specific mortality is unproven. Objective The objective was to evaluate the effect of ...
Roy Sk, A M Tomkins, S. M. Akramuzzaman, R.H. Behrens et al.
<h3>OBJECTIVE</h3> To evaluate the impact of zinc supplementation on the clinical course, stool weight, duration of diarrhoea, changes in serum zinc, and body weight gain of children with acute diarrhoea. <h3>DESIGN</h3> Randomised double blind controlled trial. Children were assigned to receive zin...
AK Mitra, Dilip Mahalanabis, Hasan Ashraf, Leanne Unicomb et al.
The therapeutic efficacy of hyperimmune bovine colostrum (HBC) from cows immunized with four serotypes of human rotavirus was evaluated in a double-blind, randomized trial in 75 boys, aged 6-24 months, infected with rotavirus diarrhoea. The treatment group received 100 ml of HBC three times a day fo...
M A Islam, Mosiur Rahman, Dilip Mahalanabis
OBJECTIVE: To examine the relation of maternal and socioeconomic factors with the development of severe malnutrition in young children. DESIGN: A case-control study. SETTING: A large diarrhoea treatment centre in a metropolitan city. SUBJECTS: Cases were 125 severely malnourished children, aged < 36...
Nur Alam, Rémy Meier, Heinz Schneider, Shafiqul Alam Sarker et al.
BACKGROUND: Partially hydrolyzed guar gum (Benefiber; Novartis Nutrition, Minneapolis, MN, U.S.A.) is fermented by colonic bacteria liberating short-chain fatty acids (SCFAs), which accelerate colonic absorption of salt and water. The purpose of this study was to evaluate the effect of Benefiber (BF...
MJ Haskell, GJ Handelman, JM Peerson, A. Daniel Jones et al.
Hepatic stores of vitamin A were estimated in 31 Bangladeshi surgical patients (15 males and 16 females) by the deuterated-retinol-dilution (DRD) technique and by analysis of the vitamin A concentration of a liver biopsy specimen obtained during previously scheduled abdominal surgery. Patients range...
Roy Sk, AM Tomkins, Rukhsana Haider, RH Behren et al.
Objective To assess the impact of zinc supplementation during acute diarrhoea on subsequent growth and morbidity in malnourished young children. Design Double blind randomized controlled clinical trial Setting International Centre for Diarrhoeal Disease Research, Bangladesh. Subjects Sixty-five chil...
ASG Faruque, Dilip Mahalanabis, SS Haque, GJ Fuchs et al.
In a double-blind, controlled trial with a factorial design, 684 patients (aged 6 months to 2 y; excludes 6 early dropouts) with acute watery diarrhoea of 3 d or less and some dehydration, who were attending a hospital, were randomly assigned to 4 groups to receive: (a) vitamin A 4500 microg retinol...
B A Hoque, Dilip Mahalanabis, Munirul Alam, M. Sirajul Islam
Inadequate handwashing after defecation and anal cleaning practices in the Indian subcontinent is an important source of faeco-oral transmission of enteric diseases. To better understand the process as traditionally practised, 90 women in semi-rural Bangladesh were observed washing hands after defec...
Dilip Mahalanabis, M. Masudur Rahman, Shafiqul Alam Sarker, Pradip Kumar Bardhan et al.
BACKGROUND: The gastric acid barrier, an important host defence against small bowel infection, may be compromised by infection with Helicobacter pylori. In developing countries, H. pylori infection occurs early in life and prevalence of hypochlorhydria is high particularly in the malnourished, which...
Roy Sk, AM Tomkins, Dilip Mahalanabis, S. M. Akramuzzaman et al.
To evaluate the impact of zinc supplementation on the clinical recovery and body weight of children with persistent diarrhoea, a randomized, double-blind, controlled trial was conducted in 190 children with persistent diarrhoea aged between 3 and 24 months. Children were randomly allocated to receiv...