Kate S. Baker, Timothy J. Dallman, Philip Ashton, Martin Day et al.
Background Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since the 1970s, shigellosis has also been reported as a sexually transmitted infection in men who have sex with me...
Se Eun Park, Duy Pham Thanh, Christine J. Boinett, Vanessa Wong et al.
There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 s...
Thomas R. Connor, Clare R. Barker, Kate S. Baker, François‐Xavier Weill et al.
Shigella flexneri is the most common cause of bacterial dysentery in low-income countries. Despite this, S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed over half-a-century ago. Here we combine whole g...
Megan E. Carey, Ruby Jain, M. Yousuf, Mailis Maes et al.
BACKGROUND: The emergence and spread of antimicrobial resistance (AMR) pose a major threat to the effective treatment and control of typhoid fever. The ongoing outbreak of extensively drug-resistant Salmonella Typhi (S. Typhi) in Pakistan has left azithromycin as the only remaining broadly efficacio...
Christopher M. Parry, Nga Tran Vu Thieu, Christiane Dolecek, Abhilasha Karkey et al.
Azithromycin is an effective treatment for uncomplicated infections with Salmonella enterica serovar Typhi and serovar Paratyphi A (enteric fever), but there are no clinically validated MIC and disk zone size interpretative guidelines. We studied individual patient data from three randomized control...
Pham Thanh Duy, Sabina Dongol, Abhishek Giri, Nguyen Thi Nguyen To et al.
Abstract Background Typhoid fever remains a significant cause of morbidity and mortality in Asia and Africa. The emergence of azithromycin resistance in South Asia is concerning, as azithromycin is one of the last effective oral drugs for treating typhoid. Objectives To describe the molecular mechan...
Christopher M. Parry, Chau Tran Thuy, Sabina Dongol, Abhilasha Karkey et al.
Infections with Salmonella enterica serovar Typhi isolates that have reduced susceptibility to ofloxacin (MIC ≥ 0.25 μg/ml) or ciprofloxacin (MIC ≥ 0.125 μg/ml) have been associated with a delayed response or clinical failure following treatment with these antimicrobials. These isolates are not dete...
Se Eun Park, Duy Pham Thanh, Gi Deok Pak, Ursula Panzner et al.
Background Invasive non-typhoidal Salmonella (iNTS) is one of the leading causes of bacteraemia in sub-Saharan Africa. We aimed to provide a better understanding of the genetic characteristics and transmission patterns associated with multi-drug resistant (MDR) iNTS serovars across the continent. Me...
Nguyen Tien Huy, R Matthew Chico, Vuong Thanh Huan, Hosam Shaikhkhalil et al.
BACKGROUND: Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This study aimed to describe the level of awareness and preparedness of hospital HCWs at the time of the first wave. METHODS: This multinational, multicenter, cross-secti...
Nga Tran Vu Thieu, Tan Trinh Van, Anh Tran Tuan, Elizabeth J. Klemm et al.
OBJECTIVES: The diagnosis of typhoid fever is a challenge. Aiming to develop a typhoid diagnostic we measured antibody responses against Salmonella Typhi (S. Typhi) protein antigens and the Vi polysaccharide in a cohort of Bangladeshi febrile patients. METHODS: IgM against 12 purified antigens and t...
Abhishek Giri, Abhilasha Karkey, Sabina Dongol, Amit Arjyal et al.
<ns3:p> <ns3:bold>Background:</ns3:bold> Typhoid and paratyphoid fever (enteric fever) is a common cause of non-specific febrile infection in adults and children presenting to health care facilities in low resource settings such as the South Asia. A 7-day course of a single oral antimicrobial such a...
Duy, Pham Thanh, Dongol, Sabina, Giri, Abhishek, Nguyen To, Nguyen Thi et al.
BACKGROUND: Typhoid fever remains a significant cause of morbidity and mortality in Asia and Africa. The emergence of azithromycin resistance in South Asia is concerning, as azithromycin is one of the last effective oral drugs for treating typhoid. OBJECTIVES: To describe the molecular mechanism and...
Pham Thanh Duy, Sabina Dongol, Abhishek Giri, To Nguyen Thi Nguyen et al.
Abstract Typhoid fever remains a significant cause of morbidity and mortality in Asia and Africa. The emergence of azithromycin resistance in South Asia is concerning, as azithromycin is one of the last effective oral drugs for treating typhoid. In mid-2019, three azithromycin-resistant (Azith R ) S...
Megan E. Carey, Ruby Jain, M. Yousuf, Mailis Maes et al.
Abstract Background The emergence and spread of antimicrobial resistance (AMR) pose a major threat to the effective treatment and control of typhoid fever. The ongoing outbreak of extensively drug resistant (XDR) Salmonella Typhi ( S . Typhi) in Pakistan has left azithromycin as the only remaining b...
Abhishek Giri, Abhilasha Karkey, Sabina Dongol, Amit Arjyal et al.
<ns4:p> <ns4:bold>Background:</ns4:bold> Typhoid and paratyphoid fever (enteric fever) is a common cause of non-specific febrile infection in adults and children presenting to health care facilities in low resource settings such as the South Asia. A 7-day course of a single oral antimicrobial such a...
Pham Thanh Duy
Review:This study provides timely evidence of a ceftriaxone-resistant Salmonella Typhi outbreak in Bangladesh, highlighting the critical role of genomic surveillance in monitoring emerging antimicrobial resistant variants.Typhoid fever is a systemic disease requiring prompt antibiotic treatment to p...
Hidemasa Izumiya, John Gunn, Peter Muturi, Pham Thanh Duy
Reviewer(s): H Izumiya (National Institute of Infectious Diseases, Tokyo) | 📗📗📗📗◻️ • J Gunn & P Muturi (The Ohio State University) | 📗📗📗📗◻️ • P T Duy (Oxford University Clinical Research Unit) | 📘📘📘📘📘
Marc J. M. Bonten
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Background: The Global Typhoid Genomics Consortium was established to...
Marc J. M. Bonten, Lauren A. Cowley
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Background: The Global Typhoid Genomics Consortium was established to...
Bawadi Abdullah, Sureena Abdullah, Abrar Zadeed Ahmed, Rawan Al Natour et al.