Ibrahim A Khalil, Chrisopher roeger, Brigee F. Blacker, Puja C Rao e al.
BACKGROUND: Shigella and enterotoxigenic Escherichia coli (ETEC) are bacterial pathogens that are frequently associated with diarrhoeal disease, and are a significant cause of mortality and morbidity worldwide. The Global Burden of Diseases, Injuries, and Risk Factors study 2016 (GBD 2016) is a syst...
Jason B Harris, Regina C LaRocque, Firdausi Qadri, Edward T Ryan et al.
Cholera is an acute, secretory diarrhoea caused by infection with Vibrio cholerae of the O1 or O139 serogroup. It is endemic in more than 50 countries and also causes large epidemics. Since 1817, seven cholera pandemics have spread from Asia to much of the world. The seventh pandemic began in 1961 a...
Sarah K. Wise, Cecelia Damask, Lauren T. Roland, Charles S. Ebert et al.
BACKGROUND: In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics ...
Jason B. Harris, Regina C. LaRocque, Fahima Chowdhury, Ashraful Islam Khan et al.
BACKGROUND: Despite recent progress in understanding the molecular basis of Vibrio cholerae pathogenesis, there is relatively little knowledge of the factors that determine the variability in human susceptibility to V. cholerae infection. METHODS AND FINDINGS: We performed an observational study of ...
Brian Schwartz, Jason B. Harris, Ashraful Islam Khan, Regina C. LaRocque et al.
We examined demographic, microbiologic, and clinical data from patients presenting during 1988, 1998, and 2004 flood-associated diarrheal epidemics at a diarrhea treatment hospital in Dhaka, Bangladesh. Compared with non-flood periods, individuals presenting during flood-associated epidemics were ol...
Jason B. Harris, Ashraful Islam Khan, Regina C. LaRocque, David J. Dorer et al.
Individuals with blood group O are more susceptible than other individuals to severe cholera, although the mechanism underlying this association is unknown. To assess the respective roles of both intrinsic host factors and adaptive immune responses that might influence susceptibility to infection wi...
Lawrence A. David, Ana A. Weil, Edward T. Ryan, Stephen B. Calderwood et al.
UNLABELLED: Disability after childhood diarrhea is an important burden on global productivity. Recent studies suggest that gut bacterial communities influence how humans recover from infectious diarrhea, but we still lack extensive data and mechanistic hypotheses for how these bacterial communities ...
Ana A. Weil, Ashraful Islam Khan, Fahima Chowdhury, Regina C. LaRocque et al.
BACKGROUND: Multiple Vibrio cholerae infections in the same household are common. The objective of this study was to examine the incidence of V. cholerae infection and associated clinical symptoms in household contacts of patients with cholera and to identify risk factors for development of severe d...
Paul Farmer, Charles Patrick Almazor, Emily T. Bahnsen, Donna Barry et al.
Meeting Cholera's Challenge to Haiti and the World: A Joint Statement on Cholera Prevention and Care
Laurent Gatto, Ruedi Aebersold, Jüergen Cox, Vadim Demichev et al.
A community of researchers working in the emerging field of single-cell proteomics propose best-practice experimental and computational recommendations and reporting guidelines for studies analyzing proteins from single cells by mass spectrometry. Analyzing proteins from single cells by tandem mass ...
Long Hang, Manohar John, Muhammad Asaduzzaman, Emily A. Bridges et al.
In vivo-induced antigen technology is a method to identify proteins expressed by pathogenic bacteria during human infection. Sera from 10 patients convalescing from cholera infection in Bangladesh were pooled, adsorbed against in vitro-grown El Tor Vibrio cholerae O1, and used to probe a genomic exp...
Wolfgang Stroebe, Michelle R. vanDellen, Georgios Abakoumkin, Edward P. Lemay et al.
During the initial phase of the COVID-19 pandemic, U.S. conservative politicians and the media downplayed the risk of both contracting COVID-19 and the effectiveness of recommended health behaviors. Health behavior theories suggest perceived vulnerability to a health threat and perceived effectivene...
Aaron M. Harris, Fahima Chowdhury, Yasmin Ara Begum, Ashraful Islam Khan et al.
Bangladesh experienced severe flooding and diarrheal epidemics in 2007. We compared flood data from 2007 with 2004 and 1998 for diarrheal patients attending the ICDDR,B hospital in Dhaka. In 2007, Vibrio cholerae O1 (33%), rotavirus (12%), and enterotoxigenic Escherichia coli (ETEC) (12%) were most ...
Aaron M. Harris, Md Saruar Bhuiyan, Fahima Chowdhury, Ashraful Islam Khan et al.
Cholera, caused by Vibrio cholerae, is a noninvasive dehydrating enteric disease with a high mortality rate if untreated. Infection with V. cholerae elicits long-term protection against subsequent disease in countries where the disease is endemic. Although the mechanism of this protective immunity i...
Regina C. LaRocque, Jason B. Harris, Michelle Dziejman, Xiaoman Li et al.
ABSTRACT Understanding gene expression by bacteria during the actual course of human infection may provide important insights into microbial pathogenesis. In this study, we evaluated the transcriptional profile of Vibrio cholerae , the causative agent of cholera, in clinical specimens from cholera p...