Melissa Bauserman, Vanessa Thorsten, Tracy L. Nolen, Jackie K. Patterson et al.
BACKGROUND: Maternal mortality is a public health problem that disproportionately affects low and lower-middle income countries (LMICs). Appropriate data sources are lacking to effectively track maternal mortality and monitor changes in this health indicator over time. METHODS: We analyzed data fro..
Elizabeth M. McClure, Ana L. Garcés, Patricia L. Hibberd, Janet Moore et al.
Abstract Background The Global Network for Women's and Children’s Health Research (Global Network) conducts clinical trials in resource-limited countries through partnerships among U.S. investigators, international investigators based in in low and middle-income countries (LMICs) and a central data ...
Alan Tita, Waldemar A. Carlo, Elizabeth M. McClure, Musaku Mwenechanya et al.
BACKGROUND: The use of azithromycin reduces maternal infection in women during unplanned cesarean delivery, but its effect on those with planned vaginal delivery is unknown. Data are needed on whether an intrapartum oral dose of azithromycin would reduce maternal and offspring sepsis or death. METHO...
Seemab Naqvi, Sarah Saleem, Farnaz Naqvi, Sk Masum Billah et al.
OBJECTIVES: We sought to determine the knowledge, attitudes and practices of pregnant women regarding COVID-19 vaccination in pregnancy in seven low- and middle-income countries (LMIC). DESIGN: Prospective, observational, population-based study. SETTINGS: Study areas in seven LMICs: Bangladesh, Indi...
Seemab Naqvi, Farnaz Naqvi, Sarah Saleem, Vanessa Thorsten et al.
OBJECTIVE: To assess, on a population basis, the medical care for pregnant women in specific geographic regions of six countries before and during the first year of the coronavirus disease 2019 (COVID-19) pandemic in relationship to pregnancy outcomes. DESIGN: Prospective, population-based study. SE...
Anam Shahil Feroz, Christina R. Paganelli, Milka Bunei, Beza Eshetu et al.
Globally, more than 5 million stillbirths and neonatal deaths occur annually. For many, the cause of death (CoD) is unknown. Minimally invasive tissue sampling (MITS) has been increasingly used in postmortem examinations for ascertaining the CoD in stillbirths and neonates. Our study compared the co...
Rebecca M. Carpenter, Sk Masum Billah, Genevieve Lyons, Md Shahjahan Siraj et al.
Low birth weight (LBW) is associated with a higher risk of neonatal mortality and the development of adult-onset chronic disease. Understanding the ongoing contribution of maternal hemoglobin (Hgb) levels to the incidence of LBW in South Asia is crucial to achieve the World Health Assembly global nu...
Farnaz Naqvi, Seemab Naqvi, Sk Masum Billah, Sarah Saleem et al.
Abstract Objective We sought to understand knowledge, attitudes and practices (KAP) regarding COVID‐19 in pregnant women in seven low and middle‐income countries (LMIC). Design Population‐based prospective, observational study. Settings Study sites in DRC, Kenya, Zambia, Bangladesh, India (two sites...
Jackie K. Patterson, Vanessa Thorsten, Barry Eggleston, Tracy L. Nolen et al.
BACKGROUND: Low birth weight (LBW, < 2500 g) infants are at significant risk for death and disability. Improving outcomes for LBW infants requires access to advanced neonatal care, which is a limited resource in low- and middle-income countries (LMICs). Predictive modeling might be useful in LMICs t...
Ana Garcés, Emily MacGuire, Holly L. Franklin, Norma Alfaro et al.
BACKGROUND: Quality assurance (QA) is a process that should be an integral part of research to protect the rights and safety of study participants and to reduce the likelihood that the results are affected by bias in data collection. Most QA plans include processes related to study preparation and r...
Jennifer Hemingway‐Foday, Alan Tita, Elwyn Chomba, Musaku Mwenechanya et al.
INTRODUCTION: Maternal and neonatal infections are among the most frequent causes of maternal and neonatal mortality, and current antibiotic strategies have been ineffective in preventing many of these deaths. A randomised clinical trial conducted in a single site in The Gambia showed that treatment...
Elizabeth M. McClure, Robert L. Goldenberg
In this issue of The Lancet Global Health, Ann Lee and colleagues report the results of a cluster-randomised trial to screen for and treat maternal abnormal vaginal flora and asymptomatic urinary tract infection during the first half of pregnancy to reduce risk of preterm birth in a low-income regio...
Waldemar A. Carlo, Alan Tita, Janet Moore, Musaku Mwenechanya et al.
BACKGROUND: In 2023, the Azithromycin Prevention in Labor Use (A-PLUS) trial showed intrapartum azithromycin reduces maternal sepsis or death in women with planned vaginal delivery in low-resource settings, but whether it reduces maternal infection is unknown. We aimed to evaluate the effectiveness ...
Sarah Saleem, Haleema Yasmin, Janet Moore, Anum Rahim et al.
OBJECTIVE: To describe the intrapartum and postpartum use of non-study antibiotics in low- and middle-income countries (LMICs) during the double-blinded NICHD Global Network Azithromycin in Labor (A-PLUS) trial. DESIGN: The antibiotic use sub-study was a planned prospective, observational sub-study ...
Robert L. Goldenberg, Sarah Saleem, Sk Masum Billah, Jean Kim et al.
OBJECTIVES: To determine COVID-19 antibody positivity rates over time and relationships to pregnancy outcomes in low- and middle-income countries (LMICs). DESIGN: With COVID-19 antibody positivity at delivery as the exposure, we performed a prospective, observational cohort study in seven LMICs duri...