James A Platts-Mills, Jie Liu, Elizabeth T. Rogawski McQuade, Furqan Kabir et al.
BACKGROUND: Optimum management of childhood diarrhoea in low-resource settings has been hampered by insufficient data on aetiology, burden, and associated clinical characteristics. We used quantitative diagnostic methods to reassess and refine estimates of diarrhoea aetiology from the Etiology, Risk...
Elizabeth T. Rogawski McQuade, Jie Liu, James A Platts-Mills, Furqan Kabir et al.
BACKGROUND: Enteropathogen infections in early childhood not only cause diarrhoea but contribute to poor growth. We used molecular diagnostics to assess whether particular enteropathogens were associated with linear growth across seven low-resource settings. METHODS: We used quantitative PCR to dete...
Elizabeth T. Rogawski McQuade, James A Platts-Mills, Jessica C. Seidman, Sushil John et al.
Antibiotics can be a lifesaving treatment for children with bacterial infections and are the most commonly prescribed therapy among all medications given to children. Furthermore, both at the individual and population levels, antibiotic overuse drives the development and transmission of antimicrobia...
Caroline Amour, Jean Gratz, Estomih Mduma, Erling Svensen et al.
BACKGROUND: Enteropathogen infections have been associated with enteric dysfunction and impaired growth in children in low-resource settings. In a multisite birth cohort study (MAL-ED), we describe the epidemiology and impact of Campylobacter infection in the first 2 years of life. METHODS: Children...
Elizabeth T. Rogawski McQuade, Luther A. Bartelt, James A Platts-Mills, Jessica C. Seidman et al.
BACKGROUND.: Giardia are among the most common enteropathogens detected in children in low-resource settings. We describe here the epidemiology of infection with Giardia in the first 2 years of life in the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Conseq...
Elizabeth T. Rogawski McQuade, Richard L. Guerrant, Alexandre Havt, Ila F.N. Lima et al.
BACKGROUND: Enteroaggregative E. coli (EAEC) have been associated with mildly inflammatory diarrhea in outbreaks and in travelers and have been increasingly recognized as enteric pathogens in young children with and without overt diarrhea. We examined the risk factors for EAEC infections and their a...
Elizabeth T. Rogawski McQuade, Fariha Shaheen, Furqan Kabir, Arjumand Rizvi et al.
Culture-independent diagnostics have revealed a larger burden of Shigella among children in low-resource settings than previously recognized. We further characterized the epidemiology of Shigella in the first two years of life in a multisite birth cohort. We tested 41,405 diarrheal and monthly non-d...
Rebecca J. Scharf, Elizabeth T. Rogawski McQuade, Laura E. Murray‐Kolb, Angelina Maphula et al.
Abstract Although many studies around the world hope to measure or improve developmental progress in children to promote community flourishing and productivity, growth is sometimes used as a surrogate because cognitive skills are more difficult to measure. Our objective was to assess how childhood m...
Amanda E. Schnee, Rashidul Haque, Mami Taniuchi, Md. Jashim Uddin et al.
Childhood diarrhea in low-resource settings has been variably linked to linear growth shortfalls. However, the association between etiology-specific diarrhea and growth has not been comprehensively evaluated. We tested diarrheal stools collected from the Performance of Rotavirus and Oral Polio Vacci...
Jessica A. Grembi, Audrie Lin, Md Abdul Karim, Md Ohedul Islam et al.
BACKGROUND: We evaluated the impact of low-cost water, sanitation, handwashing (WSH) and child nutrition interventions on enteropathogen carriage in the WASH Benefits cluster-randomized controlled trial in rural Bangladesh. METHODS: We analyzed 1411 routine fecal samples from children 14±2 months ol...
Elizabeth T. Rogawski McQuade, James A Platts-Mills, E. Ross Colgate, Rashidul Haque et al.
Background: The low efficacy of rotavirus vaccines in clinical trials performed in low-resource settings may be partially explained by acquired immunity from natural exposure, especially in settings with high disease incidence. Methods: In a clinical trial of monovalent rotavirus vaccine in Banglade...
Timothy L. McMurry, Elizabeth T. Rogawski McQuade, Jie Liu, Gagandeep Kang et al.
BACKGROUND: Prolonged enteropathogen shedding after diarrhea complicates the identification of etiology in subsequent episodes and is an important driver of pathogen transmission. A standardized approach has not been applied to estimate the duration of shedding for a wide range of pathogens. METHODS...
Elizabeth T. Rogawski McQuade, Jie Liu, Gagandeep Kang, Margaret Kosek et al.
BACKGROUND: The degree of protection conferred by natural immunity is unknown for many enteropathogens, but it is important to support the development of enteric vaccines. METHODS: We used the Andersen-Gill extension of the Cox model to estimate the effects of previous infections on the incidence of...
Elizabeth T. Rogawski McQuade, Isobel M. Blake, Stephanie A. Brennhofer, Md Ohedul Islam et al.
BACKGROUND: Clinical surveillance for COVID-19 has typically been challenging in low-income and middle-income settings. From December, 2019, to December, 2021, we implemented environmental surveillance in a converging informal sewage network in Dhaka, Bangladesh, to investigate SARS-CoV-2 transmissi...
Stephanie A. Richard, Benjamin McCormick, Laura E. Murray‐Kolb, Gwenyth O. Lee et al.
BACKGROUND: Poor growth in early childhood has been associated with increased risk of mortality and morbidity, as well as long-term deficits in cognitive development and economic productivity. OBJECTIVES: Data from the MAL-ED cohort study were used to identify factors in the first 2 y of life that a...