Michael K. Lo, Friederike Feldmann, Joy Gary, Robert Jordan et al.
spp. fruit bats, to humans, it causes respiratory and neurological disease with a case-fatality rate about 70%. Human-to-human transmission has been observed during Nipah virus outbreaks in Banglash and India. A therapeutic treatment for Nipah virus disease is urgently need. Here, we tested the ...
Blair L. DeBuysscher, Emmie de Wit, Vincent J. Munster, Dana Scott et al.
Nipah virus is a zoonotic pathogen that causes severe disease in humans. The mechanisms of pathogenesis are not well described. The first Nipah virus outbreak occurred in Malaysia, where human disease had a strong neurological component. Subsequent outbreaks have occurred in Bangladesh and India and...
Emmie de Wit, Vincent J. Munster
Nipah virus is an emerging virus infection that causes yearly disease outbreaks with high case fatality rates in Bangladesh. Nipah virus causes encephalitis and systemic vasculitis, sometimes in combination with respiratory disease. Pteropus species fruit bats are the natural reservoir of Nipah viru...
Emmie de Wit, Joseph Prescott, Darryl Falzarano, Trenton Bushmaker et al.
Since 2001, outbreaks of Nipah virus have occurred almost every year in Bangladesh with high case-fatality rates. Epidemiological data suggest that in Bangladesh, Nipah virus is transmitted from the natural reservoir, fruit bats, to humans via consumption of date palm sap contaminated by bats, with ...
Kristine A Moore, Angela J Mehr, Julie Ostrowsky, Angela K. Ulrich et al.
Nipah virus causes highly lethal disease, with case-fatality rates ranging from 40% to 100% in recognised outbreaks. No treatments or licensed vaccines are currently available for the prevention and control of Nipah virus infection. In 2019, WHO published an advanced draft of a research and developm...
Laura Baseler, Emmie de Wit, Dana Scott, Vincent J. Munster et al.
Nipah virus is a paramyxovirus in the genus Henipavirus, which has caused outbreaks in humans in Malaysia, India, Singapore, and Bangladesh. Whereas the human cases in Malaysia were characterized mainly by neurological symptoms and a case fatality rate of ∼40%, cases in Bangladesh also exhibited res...
Raúl Gómez Román, Lin‐Fa Wang, Benhur Lee, Kim Halpin et al.
Nipah disease is listed as one of the WHO priority diseases that pose the greatest public health risk due to their epidemic potential. More than 200 experts from around the world convened in Singapore last year to mark the 20th anniversary of the first Nipah virus outbreaks in Malaysia and Singapore...
Laura Baseler, Dana Scott, Greg Saturday, Eva Horne et al.
BACKGROUND: Nipah virus causes respiratory and neurologic disease with case fatality rates up to 100% in individual outbreaks. End stage lesions have been described in the respiratory and nervous systems, vasculature and often lymphoid organs in fatal human cases; however, the initial target organs ...
Neeltje van Doremalen, Victoria A. Avanzato, Kerry Goldin, Friederike Feldmann et al.
Nipah virus (NiV) is a highly pathogenic and re-emerging virus, which causes sporadic but severe infections in humans. Currently, no vaccines against NiV have been approved. We previously showed that ChAdOx1 NiV provides full protection against a lethal challenge with NiV Bangladesh (NiV-B) in hamst...
Emmie de Wit, Friederike Feldmann, Jacqueline Cronin, Kerry Goldin et al.
BACKGROUND: Nipah virus (NiV) causes recurrent outbreaks of lethal respiratory and neurological disease in Southeast Asia. The World Health Organization considers the development of an effective vaccine against NiV a priority. METHODS: We produced two NiV vaccine candidates using the licensed VSV-EB...
Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahid, Ali Fazal Khan, Ali Faisal Saleem et al.
Background: A better understanding of which children are likely to die during acute illness will help clinicians and policy makers target resources at the most vulnerable children. We used machine learning to characterise mortality in the 30-days following admission and the 180-days after discharge ...
Céline Bourdon, Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahid, Md Alfazal Khan et al.
Background: Growth faltering is well-recognized during acute childhood illness and growth acceleration during convalescence, with or without nutritional therapy, may occur. However, there are limited recent data on growth after hospitalization in low- and middle-income countries. Methods: We evaluat...
Xuan Liu, Jay R. Turner, Christopher R. Oxford, Jacob McNeill et al.
Global ground-level measurements of elements in ambient particulate matter (PM) can provide valuable information to understand the distribution of dust and trace elements, assess health impacts, and investigate emission sources. We use X-ray fluorescence spectroscopy to characterize the elemental co...
Kerry Goldin, Yanling Liu, Rebecca Rosenke, Jessica Prado-Smith et al.
BACKGROUND: Nipah virus is an emerging zoonotic virus that causes severe respiratory disease and meningoencephalitis. The pathophysiology of Nipah virus meningoencephalitis is poorly understood. METHODS: We have collected the brains of African green monkeys during multiple Nipah virus, Bangladesh st...
Yuxuan Ren, Christopher R. Oxford, Dandan Zhang, Xuan Liu et al.
Characterizing black carbon (BC) on a fine scale globally is essential for understanding its climate and health impacts. However, sparse BC mass measurements in different parts of the world and coarse model resolution have inhibited evaluation of global BC emission inventories. Here, we apply global...
Adino Tesfahun Tsegaye, Patricia B. Pavlinac, Lynnth Turyagyenda, Abdoulaye Hama Diallo et al.
Background: Current guidelines for the management of childhood wasting primarily focus on the provision of therapeutic foods and the treatment of medical complications. However, many children with wasting live in food-secure households, and multiple studies have demonstrated that the etiology of was...
Riffat Ara Shawon, Donna M. Denno, Kirkby D. Tickell, Michael Atuhairwe et al.
OBJECTIVES: This study evaluated the prevalence and correlates of guideline non-adherence for common childhood illnesses in low-resource settings. DESIGN AND SETTING: We used secondary cross-sectional data from eight healthcare facilities in six Asian and African countries. PARTICIPANTS: A total of ...
Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahid, Md Alfazal Khan, Ali Faisal Saleem et al.
Abstract Objectives Mortality during acute illness among children in low- and middle-income settings remain unacceptably high and there is increasing recognition of the importance of post-discharge mortality. A comprehensive understanding of pathways underlying mortality among acutely ill children i...
Manmeet Singh, Kerry Goldin, Meaghan Flagg, Brandi N. Williamson et al.
Nipah virus (NiV) is a highly pathogenic Paramyxovirus associated with outbreaks in Malaysia, Bangladesh, and India with high mortality rates. NiV infection causes fatal respiratory and neurological disease. The majority of survivors suffer from long-term neurological sequelae or late onset and rela...
Yan Shao, Shuyi Wang, Bonface M. Gichuki, Mark Stares et al.
Bifidobacterium longum and B. infantis are pioneer colonizers of the neonatal gut and are widely used as probiotics to support infant growth, development, and disease resistance. However, commercial strains derived largely from high-income countries (HICs) may be suboptimal for infants in low- and m...