Ariful Haque Mollik, Azmal Ibna Hassan, T. K. Paul, Mariz Sintaha et al.
Bagerhat district is in the southern portion of Bangladesh and contains a portion of the world's largest mangrove forest, the Sunderbans. The Rupsha River flows through the district and falls into the Bay of Bengal after passing through the Sunderbans forest. Because of the coastal position of the d...
Farjana Akther Noor, Nusrat Sultana, Golam Sarower Bhuyan, Md Tarikul Islam et al.
BACKGROUND: ß-thalassemia is one of the most common inherited blood disorders in the world and a major deterrent to the public health of Bangladesh. The management of thalassemia patients requires lifelong frequent blood transfusion and the available treatment options are unsatisfactory. A national ...
Suprovath Kumar Sarker, Md Tarikul Islam, Aparna Biswas, Golam Sarower Bhuyan et al.
Liquid Chromatography tandem mass spectrometry (LC-MS/MS) is used for the diagnosis of more than 30 inborn errors of metabolisms (IEMs). Accurate and reliable diagnosis of IEMs by quantifying amino acids (AAs) and acylcarnitines (ACs) using LC-MS/MS systems depend on the establishment of age-specifi...
Kazi Sarjana Safain, Golam Sarower Bhuyan, Sadia Tasnim, Saad S. M. Hassan et al.
The study investigated the spectrum of antibiotic resistance and the associated genes for aminoglycoside, macrolide and ESBL class of antibiotics using clinical isolates. A total of 430 preserved bacterial strains (Acinetobacter baumannii, n= 20; Pseudomonas aeruginosa, n= 26; Klebsiella pneumoniae,...
Kazi Sarjana Safain, Golam Sarower Bhuyan, Saad S. M. Hassan, Mohammad Sazzadul Islam et al.
OBJECTIVES: Characterisation of resistance phenotype and genotype is crucial to understanding the burden and transmission of antimicrobial resistance (AMR). This study aims to determine the spectrum of AMR and associated genes encoding aminoglycoside, macrolide and β-lactam classes of antimicrobials...
Golam Sarower Bhuyan, Aftab Uz Zaman Noor, Rosy Sultana, Farjana Akther Noor et al.
Transfusion transmitted infections have remained a major deterrent to public health, particularly among the patients with transfusion-dependent Beta thalassemia in developing countries. Although proper donor selection through adoption of WHO-advised infection panel has lowered the rate of infections...
Md. Walid Hossain, Mohabbat Hossain, Khalid Arafath, Subarna Sayed Ety et al.
The study aimed to shorten multiplex RT-PCR run time for detection of SARS CoV-2 N1 and N2 sequences and human RNase P (RP) sequence as internal mRNA control using conventional and designated real time thermal cycler systems. Optimization of Fast PCR protocol using plasmid-based N1 and N2 positive c...
Farjana Akther Noor, Kazi Sarjana Safain, Md. Walid Hossain, Khalid Arafath et al.
Background The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is posing a great threat to global health and economy. Due to the lack of broad diagnostic setup, consistent reagent supply lines, and access to laboratory instruments and equipment, it is undoubtedly a...
Rosy Sultana, Md Tarikul Islam, Golam Sarower Bhuyan, Suprovath Kumar Sarker et al.
OBJECTIVES: To determine IgG immune responses and hepatitis E virus (HEV) viral load, and to explore the associations with pregnancy. METHODS: A total of 121 HEV-infected women (57 pregnant, 64 non-pregnant) were analysed. Quantitative reverse transcription PCR (RT-qPCR) was done for 78 HEV IgM-posi...
Kaiissar Mannoor, Mohabbat Hossain, Farjana Akther Noor, Golam Sarwer Bhuyan et al.
Background: Thalassaemia is one of the most common genetic blood disorders worldwide. Patients with β-thalassaemia major and HbE/β-thalassaemia are blood transfusion dependent. Foetal haemoglobin or HbF can play a role in disease manifestations in these patients and there is evidence that a homozygo...
Md Tarikul Islam, Nusrat Sultana, Suprovath Kumar Sarker, Tanvir Hossain et al.
Different mutations in the beta-globin gene impose clinical heterogeneity in the affected individuals, such as patients with Hb E disease are asymptomatic and non-transfusion-dependent. Conversely, the transfusion-dependent patients with EBT require blood transfusion with varying degrees of transfus...
Golam Sarower Bhuyan, Aftab Uz Zaman Noor, Rosy Sultana, Farjana Akther Noor et al.
Abstract Transfusion transmitted infections (TTIs) have remained a major deterrent to public health, particularly among the patients with transfusion-dependent Beta thalassemia in developing countries. Although proper donor selection through adoption of WHO-advised infection panel has lowered the ra...
Farjana Akther Noor, Mohabbat Hossain, Suprovath Kumar Sarker, Khalid Arafath et al.
Abstract Patients with HbE/β-thalassemia inheriting the same β-globin mutations display varied clinical manifestations, the mechanism of which is only partially known. The study aimed to decipher the heterogenous basis of HbE/β-thalassemia patients in more details by focusing on both hematological a...
Rumana Mahtarin, Kasrina Azad, Rakib Bin Mahbub Talukder, Rynak Rahmat et al.
BACKGROUND: β-thalassemia poses a considerable public health burden in Bangladesh, where a high carrier frequency underlies widespread disease risk. It is necessary to distinguish β-thalassemia trait (βTT) and iron deficiency anemia (IDA) to ensure genetic counseling and enable effective prevention ...
Rumana Mahtarin, Kasrina Azad, Rakib Bin Mahbub Talukder, Rynak Rahmat et al.
<div> Background β-thalassemia poses a considerable public health burden in Bangladesh, where a high carrier frequency underlies widespread disease risk. It is necessary to distinguish β-thalassemia trait (βTT) and iron deficiency anemia (IDA) to ensure genetic counseling and enable effective preven...
Rumana Mahtarin, Kasrina Azad, Rakib Bin Mahbub Talukder, Rynak Rahmat et al.
Discriminant formulas applied for the evaluation of the diagnosis of β-thalassemia trait (βTT) in the Bangladeshi population.
Rumana Mahtarin, Kasrina Azad, Rakib Bin Mahbub Talukder, Rynak Rahmat et al.
<div> Background β-thalassemia poses a considerable public health burden in Bangladesh, where a high carrier frequency underlies widespread disease risk. It is necessary to distinguish β-thalassemia trait (βTT) and iron deficiency anemia (IDA) to ensure genetic counseling and enable effective preven...
Md. Mahade Hasan Shetu, Farjana Akther Noor, Mazbahul Kabir, Md. Asadur Rahman et al.
Abstract Background A key component of diagnostics in low- and middle-income (LMIC) nations is polymerase chain reaction (PCR). Despite its high sensitivity, PCR is vulnerable to laboratory contamination, particularly from aerosolized DNA. Glycerol, a common additive that enhances enzyme activity, m...
Rumana Mahtarin, Kasrina Azad, Mohabbat Hossain, Mst. Sharmin Aktar Mukta et al.
Abstract Thalassemia is a hereditary blood disorder with different severity spectrums. This study aimed to assess thalassemia screening rates between children of Bangladesh and selected camps of Forcibly Displaced Myanmar Nationals (FDMN) in Cox’s Bazar in Bangladesh and compare the hematological pa...
Farjana Akther Noor, Songjukta Chakraborty, Christophe Wiart, Mohammed Rahmatullah
Olanzapine is an antipsychotic drug and has been reported to induce impaired glucose tolerance leading to high blood glucose levels. In oral glucose tolerance tests (OGTT), methanolic extract of steamed cabbage (Brassica oleracea L. var. capitata) (MEBO) leaves have been shown to reduce elevated blo...