Marie Ng, Tom Fleming, Margaret S. Robinson, Blake Thomson et al.
Background In 2010, overweight and obesity were estimated to cause 3.4 million deaths, 3.9% of years of life lost, and 3.8% of DALYs globally. The rise in obesity has led to widespread calls for regular monitoring of changes in overweight and obesity prevalence in all populations. Comparative, up-to...
Charge Diabetes Working Group, Dajiang J. Liu, VA Million Veteran Program, Gina M. Peloso et al.
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein ch...
Paolo Zanoni, Sumeet A. Khetarpal, Daniel B. Larach, William Hancock‐Cerutti et al.
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C l...
Shengxiong Huang, Yongfeng Gao, Ji‐Kai Liu, Xiaoli Peng et al.
The WRKY transcription factors have been implicated in multiple biological processes in plants, especially in regulating defense against biotic and abiotic stresses. However, little information is available about the WRKYs in tomato (Solanum lycopersicum). The recent release of the whole-genome sequ...
Fei Chen, Lian‐Lian Liu, Jing‐Hang Wu, Xianhong Rui et al.
Abstract Single‐atom catalysts have emerged as an efficient oxidant activator for eliminating organic pollutants in Fenton‐like systems. However, the complex preparation, single active site, lack of understanding of the fundamental mechanism, and harsh pH conditions currently limit their practical a...
Shentan Liu, Hai–Liang Song, Size Wei, Fei Yang et al.
To optimize the performance of a vertical subsurface flow constructed wetland-microbial fuel cell (CW-MFC), studies of bio-cathode materials and reactor configurations were carried out. Three commonly used bio-cathode materials including stainless steel mesh (SSM), carbon cloth (CC) and granular act...
Md. Abdul Mazid, Carl Ward, Zhiwei Luo, Chuanyu Liu et al.
After fertilization, the quiescent zygote experiences a burst of genome activation that initiates a short-lived totipotent state. Understanding the process of totipotency in human cells would have broad applications. However, in contrast to in mice 1,2 , demonstration of the time of zygotic genome a...
Fei Huang, Pan Liu, Hao Yu, Wei Wang
The primary objective of this study was to identify if the VISSIM simulation model and the Surrogate Safety Assessment Model (SSAM) approach provided reasonable estimates for the traffic conflicts measured at signalized intersections. A total of 80h of traffic data and traffic conflicts data were co...
Bin Wang, Guosen Chen, Fei Liu
Madden-Julian Oscillation (MJO) is the dominant mode of atmospheric intraseasonal variability and the cornerstone for subseasonal prediction of extreme weather events. Climate modeling and prediction of MJO remain a big challenge, partially due to lack of understanding the MJO diversity. Here, we de...
Meiling Su, Chaofei Chen, Shaoying Li, Musheng Li et al.
Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, but their contributions to rapid clinical deterioration and dysregulated inflammation have not been defined. Here, we show that the incidence of thrombocytopathy and inflammatory cytokine release was significantl...
Gowri Manohari Arumugam, Santhosh Kumar Karunakaran, Chong Liu, Cuiling Zhang et al.
Abstract In the past decades, the inverted structure (p‐i‐n structure) perovskite solar cells (PVSCs) have been attracted more by the researchers owing to their ease of fabrication, cost‐effectiveness, lower processing temperature for the fabrication of large scale and flexible devices with negligib...
Kathryn Thomson, Calie Dyer, Feiyan Liu, Kirsty Sands et al.
BACKGROUND: Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of neonatal sepsis. In the BARNARDS observational cohort study of neonatal sepsis and antimicr...
YaLi Deng, Derong Tang, Pan‐Fei Hou, Weitao Shen et al.
A number of studies have identified that gut microbiota influences the development of cancer. However, there is little known about gut microbiota and esophageal cancer (EC). The aim of this study was to investigate the gut microbiota profile associated with EC. In this study, 23 patients with EC and...
Erick Andres Perez Alday, Annie Gu, Amit Shah, Chad Robichaux et al.
Abstract The subject of the PhysioNet/Computing in Cardiology Challenge 2020 was the identification of cardiac abnormalities in 12-lead electrocardiogram (ECG) recordings. A total of 66,405 recordings were sourced from hospital systems from four distinct countries and annotated with clinical diagnos...
Fei Xue, Jing Cheng, Yan Liu, Cheng Cheng et al.
Abstract Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating diabetic cardiomyopathy (DCM) but has been found to be a substrate of a disintegrin and metalloprotease protein-17 (ADAM17). However, whether ADAM17 plays a role in the pathogenesis and intervention of DCM is obscur...