Jie Liu, James A Platts-Mills, Jane Juma, Furqan Kabir et al.
Background Diarrhoea is the second leading cause of mortality in children worldwide, but establishing the cause can be complicated by diverse diagnostic approaches and varying test characteristics. We used quantitative molecular diagnostic methods to reassess causes of diarrhoea in the Global Enteri...
Jennifer Luedtke, Janice Chanson, Kelsey Neam, Louise Hobin et al.
Abstract Systematic assessments of species extinction risk at regular intervals are necessary for informing conservation action 1,2 . Ongoing developments in taxonomy, threatening processes and research further underscore the need for reassessment 3,4 . Here we report the findings of the second Glob...
Christopher J L Murray, Cristiana Abbafati, Kaja Abbas, Mohammad Hossein Abbasi et al.
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first ...
Dennis Egger, Edward Miguel, Shana S. Warren, Ashish Shenoy et al.
Despite numerous journalistic accounts, systematic quantitative evidence on economic conditions during the ongoing COVID-19 pandemic remains scarce for most low- and middle-income countries, partly due to limitations of official economic statistics in environments with large informal sectors and sub...
David M. Reimers, Stephan Thernstrom
Groups and Definitions Acadians Marietta M. LeBreton Afghans David C. Champagne Africans Afro-Americans Thomas C. Holt Albanians Aleuts Dorothy M. Jones Alsatians Frederick C. Luebke American Indians Edward H. Spicer Amish John A. Hostetler Anglo-American Anglo-Saxon Appalachians Dwight Billings and...
Willian A. da Silveira, Hossein Fazelinia, Sara Brin Rosenthal, Evagelia C. Laiakis et al.
Spaceflight is known to impose changes on human physiology with unknown molecular etiologies. To reveal these causes, we used a multi-omics, systems biology analytical approach using biomedical profiles from fifty-nine astronauts and data from NASA’s GeneLab derived from hundreds of samples flown in...
Helen E. Roy, Wolfgang Rabitsch, Riccardo Scalerà, Alan J. A. Stewart et al.
Abstract Biological invasions are a threat to biodiversity, society and the economy. There is an urgent need to provide evidence‐based assessments of the risks posed by invasive alien species ( IAS ) to prioritize action. Risk assessments underpin IAS policies in many ways: informing legislation; pr...
G Dean, Marta Elian
OBJECTIVES: Previous studies have shown that multiple sclerosis is very uncommon among Indian and Pakistani immigrants to England but that their children born in the United Kingdom, in the age groups available for study, have a similar risk of developing the disease as occurs in the general British ...
Luca Freschi, Roger Vargas, Ashaque Husain, S. M. Mostofa Kamal et al.
Mycobacterium tuberculosis is a clonal pathogen proposed to have co-evolved with its human host for millennia, yet our understanding of its genomic diversity and biogeography remains incomplete. Here we use a combination of phylogenetics and dimensionality reduction to reevaluate the population stru...
Matteo Zignol, Anna Dean, Natavan Alikhanova, Sönke Andres et al.
BACKGROUND: Pyrazinamide and fluoroquinolones are essential antituberculosis drugs in new rifampicin-sparing regimens. However, little information about the extent of resistance to these drugs at the population level is available. METHODS: In a molecular epidemiology analysis, we used population-bas...
Matteo Zignol, Andrea Maurizio Cabibbe, Anna Dean, Philippe Glaziou et al.
BACKGROUND: In many countries, regular monitoring of the emergence of resistance to anti-tuberculosis drugs is hampered by the limitations of phenotypic testing for drug susceptibility. We therefore evaluated the use of genetic sequencing for surveillance of drug resistance in tuberculosis. METHODS:...
Derek Klarin, Shefali S. Verma, Renae Judy, Ozan Dikilitas et al.
Background: Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identified risk loci explain a small fraction of AAA heritability. Methods: We performed a genome-wide association stu...
Payal Hathi, Sabrina Haque, Lovey Pant, Diane Coffey et al.
A long literature in demography has debated the importance of place for health, especially children's health. In this study, we assess whether the importance of dense settlement for infant mortality and child height is moderated by exposure to local sanitation behavior. Is open defecation (i.e., wit...
Anna Dean, Matteo Zignol, Andrea Maurizio Cabibbe, Dennis Falzon et al.
BACKGROUND: The surveillance of drug resistance among tuberculosis (TB) patients is central to combatting the global TB epidemic and preventing the spread of antimicrobial resistance. Isoniazid and rifampicin are two of the most powerful first-line anti-TB medicines, and resistance to either of them...
Masayuki Teramoto, Marissa B Reitsma, Yohannes Abate, Abdallah H A Abd Al Magied et al.
BACKGROUND: Smoking is the leading behavioural risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking prevalence has slowed in recent years for many countries, and although st...