Sam Hodgson, Alice Williamson, Margherita Bigossi, Daniel Stow et al.
Abstract South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass index (BMI). However, reasons for this are poorly understood because genetic research is largely focused on European ancestry groups. We used recently derived multi-ancestry partitioned polygenic scores...
Julia Zöllner, Binur Orazumbekova, Sam Hodgson, David A. van Heel et al.
British Pakistani and Bangladeshi (BPB) women have disproportionately high rates of gestational diabetes mellitus (GDM), with prevalence estimates up to three times higher than in the general population. They are also at increased risk of progressing to type 2 diabetes, leading to significant health...
Teng Hiang Heng, Klaudia Walter, Qin Huang, Juha Karjalainen et al.
<h2>Summary</h2> Genetic association studies have focused on testing additive models in cohorts with European ancestry. Little is known about recessive effects on common diseases, specifically for non-European ancestry. Genes & Health is a cohort of British Pakistani and Bangladeshi individuals with...
Hye In Kim, Christopher DeBoever, Klaudia Walter, Georgios Kalantzis et al.
Abstract Genes and Health (G&H) is a biomedical study of adult British-Pakistani and -Bangladeshi research volunteers enriched for autozygosity. We performed whole exome sequencing in 44,028 G&H participants, establishing the largest publicly available South Asian exome resource linked to lo...
Hye In Kim, Christopher DeBoever, Klaudia Walter, Georgios Kalantzis et al.
Genes & Health (G&H) is a biomedical study of adult British Pakistani and Bangladeshi research volunteers enriched for autozygosity. Here we performed whole-exome sequencing in 44,028 G&H participants, establishing a large publicly available South Asian exome resource linked to longitudinal electron...
Timing Liu, Alagu Sankareswaran, Gordon Paterson, Shaheen Akhtar et al.
Correct classification of type 1 (T1D) and type 2 diabetes (T2D) is challenging due to overlapping clinical features and the increasingly early onset of T2D, particularly in South Asians. Polygenic risk scores (PRSs) for T1D and T2D have been shown to work relatively well in South Asians, despite be...
Teng Hiang Heng, Klaudia Walter, Qin Huang, Juha Karjalainen et al.
Genetic association studies have focused on testing additive models in cohorts with European ancestry. Little is known about recessive effects on common diseases, specifically for non-European ancestry. Genes & Health is a cohort of British Pakistani and Bangladeshi individuals with elevated rat...
Abu Z M Dayem Ullah, Ashitha Joby, Graeme J. Thorn, Lucas M. James et al.
South Asian populations remain underrepresented in cancer genomics, despite elevated risk for certain malignancies and distinct clinical profiles. This gap is especially pronounced for British Bangladeshi and Pakistani communities. We analyse data from 57,416 individuals of Bangladeshi and Pakistani...
Sam Hodgson, Van-Minh Bui, Siqi Hu, Margherita Bigossi et al.
Abstract / Introductory Paragraph Type 2 diabetes (T2D) is a common and complex metabolic condition with significant heterogeneity within and across ancestries 1–4 . Compared with individuals of European ancestry (EUR), people of south Asian ancestry (SAS) have two to four-fold higher risk of T2D, d...