Molly L. Kile, E. Andrés Houseman, Carrie V. Breton, Thomas J. Smith et al.
BACKGROUND: Millions of people in Bangladesh are at risk of chronic arsenic toxicity from drinking contaminated groundwater, but little is known about diet as an additional source of As exposure. METHODS: We employed a duplicate diet survey to quantify daily As intake in 47 women residing in Pabna, ...
Molly L. Kile, Andrea Baccarelli, Elaine Hoffman, Letizia Tarantini et al.
BACKGROUND: Arsenic is an epigenetic toxicant and could influence fetal developmental programming. OBJECTIVES: We evaluated the association between arsenic exposure and DNA methylation in maternal and umbilical cord leukocytes. METHODS: Drinking-water and urine samples were collected when women were...
Karen L. Huyck, Molly L. Kile, Golam Mahiuddin, Quazi Quamruzzaman et al.
OBJECTIVE: To characterize the effects of maternal arsenic exposure on birth weight. METHODS: Hair, toenail, and drinking water samples were collected from pregnant women (n = 52) at multiple time points during pregnancy and from their newborns after birth. Total arsenic was measured using inductive...
Wen‐Chi Pan, Wei Jie Seow, Molly L. Kile, Elaine Hoffman et al.
Chronic exposure to high levels of arsenic in drinking water is associated with increased risk of type 2 diabetes mellitus (T2DM), but the association between lower levels of arsenic and T2DM is more controversial. Therefore, this study evaluated the association between low to moderate arsenic expos...
Molly L. Kile, Elaine Hoffman, Yu‐Mei Hsueh, Sakila Afroz et al.
BACKGROUND: Urinary arsenic metabolites (UAs) are used as biomarkers of exposure and metabolism. OBJECTIVES: To characterize inter- and intraindividual variability in UAs in healthy individuals. METHODS: In a longitudinal study conducted in Bangladesh, we collected water and spot urine samples from ...
Kathleen M. McCarty, Yen‐Ching Chen, Quazi Quamruzzaman, Mahmuder Rahman et al.
OBJECTIVE: We investigated whether primary and secondary arsenic methylation ratios were associated with skin lesions and whether GSTT1, GSTP1, and GSTM1 polymorphisms modify these relationships. METHODS: A case-control study of 600 cases and 600 controls that were frequency matched on age and sex w...
Md. Mahiuddin Zahangir, Farhana Haque, Golam Mohammod Mostakim, M. Sadiqul Islam
Stress is one of the most critical factors in fish health. The response to stress in fish is characterized by the stimulation of the hypothalamus, which results in the activation of the neuroendocrine system and a subsequent cascade of metabolic and physiological changes. The present paper deals wit...
Molly L. Kile, Elaine Hoffman, Ema Rodrigues, Carrie V. Breton et al.
Inorganic arsenic is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Limited evidence suggests that the ability to fully metabolize arsenic into DMA influences susceptibility to disease. To determine whether percentage of MMA was predictive of disease, the authors used da...
Golam Mohammod Mostakim, Md. Mahiuddin Zahangir, Mahbuba Monir Mishu, Md. Khalilur Rahman et al.
Quinalphos (QP) is commonly used for pest control in the agricultural fields surrounding freshwater reservoirs. This study was conducted to evaluate the chronic toxicity of this pesticide on blood parameters and some organs of silver barb, Barbonymus gonionotus. Fish were exposed to two sublethal co...
Molly L. Kile, E. Andrés Houseman, Ema Rodrigues, Thomas J. Smith et al.
Toenail arsenic (As) concentrations were evaluated as a biomarker of inorganic As (As(in)) exposure in a population residing in an As-endemic region of Bangladesh. Drinking water and toenail samples were collected from 48 families (n = 223) every 3 months for 2 years and analyzed for As using induct...
Zia Ahmed, Mohammad Golam Mortuza, Mohammed Jashim Uddin, Md. Humayun Kabir et al.
Enhanced and intelligent healthcare system is a symbol of developed and prosperous nation. Internet of Things (IoT) has abounded the digital healthcare system by providing remote monitoring of patients’ health condition and allowing doctors to have access to those information. This paper proposes an...
Wei Jie Seow, Wen‐Chi Pan, Molly L. Kile, Andrea Baccarelli et al.
BACKGROUND: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions. OBJECTIVE: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time. METHODS: A follow-up study of 5...
Molly L. Kile, E. Andrés Houseman, Carrie V. Breton, Quazi Quamruzzaman et al.
The association between arsenic exposure from drinking water and toenail arsenic concentrations appears to be non-linear at low exposure levels. To investigate whether this observation is a result exposure misclassification, a dietary exposure assessment was conducted in a cohort of 47 women concurr...
Carrie V. Breton, Molly L. Kile, Paul J. Catalano, Elaine Hoffman et al.
BACKGROUND: Chronic arsenic exposure is associated with an increased risk of skin, bladder and lung cancers. Generation of oxidative stress may contribute to arsenic carcinogenesis. METHODS: To investigate the association between arsenic exposure and oxidative stress, urinary 8-hydroxy-2'-deoxyguano...
Carrie V. Breton, Wei Zhou, Molly L. Kile, E. Andrés Houseman et al.
Genetic polymorphisms in the base excision DNA repair pathway may influence individual susceptibility to arsenic and the development of arsenic-induced skin lesions. Data from a case-control study of 792 cases and 792 matched controls conducted in Bangladesh from 2001 to 2003 were analyzed using con...