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Results for “"Gui-Bin Liang"”

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Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation

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Ri-Zhen Huang, Gui-Bin Liang, Xiaochao Huang, Bin Zhang et al.

Journal: European Journal of Medicinal ChemistryYear: 2017Citations: 34

A series of dehydroabietic acid (DHAA) dipeptide derivatives containing the sulfonamide moiety were designed, synthesized and evaluated for inhibition of MMPs as well as the effects of in vitro cell migration. These compounds exhibited relatively good inhibition activity against MMPs with IC 50 valu...

Life SciencesBiochemistry, Genetics and Molecular BiologyCancer ResearchOpen Access
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