Gilles R. Dagenais, Hertzel C. Gerstein, Xiaohe Zhang, Matthew McQueen et al.
OBJECTIVE: The goal of this study was to assess whether diabetes prevalence varies by countries at different economic levels and whether this can be explained by known risk factors. RESEARCH DESIGN AND METHODS: The prevalence of diabetes, defined as self-reported or fasting glycemia ≥7 mmol/L, was d...
Clara K Chow, Chinthanie Ramasundarahettige, Weihong Hu, Khalid F. AlHabib et al.
BACKGROUND Data are scarce on the availability and affordability of essential medicines for diabetes. Our aim was to examine the availability and affordability of metformin, sulfonylureas, and insulin across multiple regions of the world and explore the effect of these on medicine use. METHODS In th...
Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Martin O’Donnell et al.
AIMS: To develop a healthy diet score that is associated with health outcomes and is globally applicable using data from the Prospective Urban Rural Epidemiology (PURE) study and replicate it in five independent studies on a total of 245 000 people from 80 countries. METHODS AND RESULTS: A healthy d...
Deepa Mohan, Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan et al.
Importance: Cohort studies report inconsistent associations between fish consumption, a major source of long-chain ω-3 fatty acids, and risk of cardiovascular disease (CVD) and mortality. Whether the associations vary between those with and those without vascular disease is unknown. Objective: To ex...
Anand Ss, Dagenais Gr, Viswanathan Mohan, Rafael Díaz et al.
AIMS: In an international prospective cohort study we assessed the relationship between glucose levels and incident cardiovascular events and death. METHODS AND RESULTS: 18,990 men and women were screened for entry into the DREAM clinical trial from 21 different countries. All had clinical and bioch...
Ranjit Mohan Anjana, Viswanathan Mohan, Sumathy Rangarajan, Hertzel C. Gerstein et al.
OBJECTIVE We aimed to compare cardiovascular (CV) events, all-cause mortality, and CV mortality rates among adults with and without diabetes in countries with differing levels of income. RESEARCH DESIGN AND METHODS The Prospective Urban Rural Epidemiology (PURE) study enrolled 143,567 adults aged 35...
Marie Loh, Weihua Zhang, Hong Kiat Ng, Katharina Schmid et al.
Abstract South Asians are at high risk of developing type 2 diabetes (T2D). We carried out a genome-wide association meta-analysis with South Asian T2D cases ( n = 16,677) and controls ( n = 33,856), followed by combined analyses with Europeans (n eff = 231,420). We identify 21 novel genetic loci fo...
Alicia Huerta‐Chagoya, Joohyun Kim, Ravi Mandla, Yingchang Lu et al.
BACKGROUND: Polygenic risk scores (PRSs) improve prediction of the development of type 2 diabetes over the use of clinical risk factors alone; however, they perform poorly in populations of non-European ancestry, limiting their global clinical utility. We aimed to deliver comprehensive and rigorousl...