Elizabeth A. Ashley, Mehul Dhorda, Rick M. Fairhurst, Chanaki Amaratunga et al.
BACKGROUND: Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. METHODS: Between May 2011 and Apri...
Olivo Miotto, Roberto Amato, Elizabeth A. Ashley, Bronwyn MacInnis et al.
We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains, ...
Weisheng Li, Xiaoshu Gong, Zhihao Yu, Liang Ma et al.
The development of next-generation electronics requires scaling of channel material thickness down to the two-dimensional limit while maintaining ultralow contact resistance 1,2 . Transition-metal dichalcogenides can sustain transistor scaling to the end of roadmap, but despite a myriad of efforts, ...
Ying Bai, Yuan Zhang, Bing Han, Li Yang et al.
Circular RNAs (circRNAs) are highly expressed in the CNS and regulate physiological and pathophysiological processes. However, the potential role of circRNAs in stroke remains largely unknown. Here, we show that the circRNA DLGAP4 (circDLGAP4) functions as an endogenous microRNA-143 (miR-143) sponge...
Emma Fulu, Stephanie Spaid Miedema, Tim Roselli, Sarah McCook et al.
BACKGROUND: Although childhood trauma and violence against women are global public health issues, few population-based data from low-income and middle-income countries exist about the links between them. We present data from the UN Multi-country Study on Men and Violence in Asia and the Pacific, exp...
David M. Geiser, Abdullah M. S. Al‐Hatmi, Takayuki Aoki, Tsutomu Arie et al.
Scientific communication is facilitated by a data-driven, scientifically sound taxonomy that considers the end-user’s needs and established successful practice. In 2013, the Fusarium community voiced near unanimous support for a concept of Fusarium that represented a clade comprising all agricultura...
Fangfang Wu, Bing Han, Shusheng Wu, Li Yang et al.
Circular RNAs (circRNAs) are expressed at high levels in the brain and are involved in various CNS diseases. However, the potential role of circRNAs in ischemic stroke-associated neuronal injury remains largely unknown. Here, we investigated the important functions of circRNA TLK1 (circTLK1) in this...
Ting Liu, Jiang Xue Dong, Shi Gang Liu, Na Li et al.
A stable silver nanoparticles/carbon quantum dots (Ag/CQDs) composite was prepared by using CQDs as reducing and stabilizing agent. The CQDs synthesized with polyethyleneimine (PEI) showed an extraordinary reducibility. When Hg 2+ was presented in the Ag/CQDs composite solution, a color change from ...
Durganand Sinha, Henry S. R. Kao
Introduction - Durganand Sinha and Henry S R Kao Values-Development Congruence PART ONE: SOCIAL VALUES AND DEVELOPMENT: GENERAL REVIEWS Basic Indian Values and Behaviour Dispositions in the Context of National Development - Durganand Sinha An ent An l Chinese Modernisation and Social Values - Lin Fa...
Meijia Yang, Xuanhe Hu, Zhengsong Fang, Lu Sun et al.
Nitrogen‐rich porous carbons (NPCs) are the leading cathode materials for next‐generation Zn–air and Li–S batteries. However, most existing NPC suffers from insufficient exposure and harnessing of nitrogen‐dopants (NDs), constraining the electrochemical performance. Herein, by combining silica templ...
Jiyang Fan, Hongxia Li, Jiang Jiang, Leo K.Y. So et al.
Silicon carbide nanocrystals are water-soluble, chemically inert, and highly fluorescent, and they may be idealas biological labels. After the uptake of3C–SiC nanocrystals, human fetal osteoblast (hFOB) cells exhibit brightgreen–yellow fluorescence (see image).The nanoparticles show high resistancea...
Jae Jeong Yang, Danxia Yu, Wanqing Wen, Eiko Saito et al.
Importance: Asia is home to the largest diabetic populations in the world. However, limited studies have quantified the association of diabetes with all-cause and cause-specific mortality in Asian populations. Objectives: To evaluate the association of diabetes with all-cause and cause-specific mort...
Zhifa Wen, Hongxiang Liu, Rong Gao, Meng Zhou et al.
<h3>Background</h3> Tumor-associated macrophages (TAMs) facilitate tumor progression via establishment of an immunosuppressive tumor microenvironment (TME). However, it is poorly understood how tumor cells could functionally modulate TAMs. Our previous work indicated that tumor cell-released autopha...
Takafumi Noguchi, Fuminori Tomosawa, Kamran M. Nemati, Bernardino Chiaia et al.
First Name is required invalid characters Last Name is required invalid characters Email Address is required Invalid Email Address Please select a country... Afghanistan Åland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Austra...
Lin Piao, Vaninder K. Sidhu, Yong-Hu Fang, John Ryan et al.
Pyruvate dehydrogenase kinase (PDK) is activated in right ventricular hypertrophy (RVH), causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. The stimulus for PDK upregulation, its isoform specificity, and the long-term effects of PDK inhibition ar...