Kimberley D. Seed, Minmin Yen, B. Jesse Shapiro, Isabelle J. Hilaire et al.
The impact of phage predation on bacterial pathogens in the context of human disease is not currently appreciated. Here, we show that predatory interactions of a phage with an important environmentally transmitted pathogen, Vibrio cholerae, can modulate the evolutionary trajectory of this pathogen d...
Richelle C. Charles, Isabelle J. Hilaire, Leslie M. Mayo-Smith, Jessica E. Teng et al.
BACKGROUND: Studies of the immunogenicity of the killed bivalent whole cell oral cholera vaccine, Shanchol, have been performed in historically cholera-endemic areas of Asia. There is a need to assess the immunogenicity of the vaccine in Haiti and other populations without historical exposure to Vib...
Louise C. Ivers, Richelle C. Charles, Isabelle J. Hilaire, Leslie M. Mayo-Smith et al.
We evaluated immune responses following bivalent oral cholera vaccination (Shanchol [Shantha Biotechnics]; BivWC) in a cohort of 25 human immunodeficiency virus (HIV)-infected adults in Haiti. Compared with adults without HIV infection, vaccination in HIV-infected individuals resulted in lower vibri...
Kimberley D. Seed, Minmin Yen, B. Jesse Shapiro, Isabelle J. Hilaire et al.
Cholera epidemics occur seasonally in areas such as Bangladesh, and outbreaks can also strike in vulnerable regions, as has occurred recently in Haiti. The disease is caused by Vibrio cholerae, a water-borne bacterium that colonizes the small intestine, and its symptoms include severe diarrhea and v...