Jeanette L. Gehrig, Siddarth Venkatesh, Hao-Wei Chang, Matthew C. Hibberd et al.
To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutr...
Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, Subhasish Das et al.
BACKGROUND: More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed development of their gut microbiota. METHOD...
Arjun S. Raman, Jeanette L. Gehrig, Siddarth Venkatesh, Hao-Wei Chang et al.
Characterizing the organization of the human gut microbiota is a formidable challenge given the number of possible interactions between its components. Using a statistical approach initially applied to financial markets, we measured temporally conserved covariance among bacterial taxa in the microbi...
Jade Benjamin‐Chung, Andrew Mertens, John M. Colford, Alan Hubbard et al.
. Stunting, a form of linear growth faltering, increases the risk of illness, impaired cognitive development and mortality. Global stunting estimates rely on cross-sectional surveys, which cannot provide direct information about the timing of onset or persistence of growth faltering-a key considerat...
Matthew C. Hibberd, Daniel M. Webber, Dmitry A. Rodionov, Suzanne Henrissat et al.
Abstract Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition 1–4 . Here we analyse biospecimens from a randomized, controlled trial of a microbiome-directed complementary food (MDCF-2) that produced superior rates of weight gain c...
Hao-Wei Chang, Evan M. Lee, William Yi Wang, Cyrus Zhou et al.
Microbiota-directed complementary food (MDCF) formulations have been designed to repair the gut communities of malnourished children. A randomized controlled trial demonstrated that one formulation, MDCF-2, improved weight gain in malnourished Bangladeshi children compared to a more calorically dens...
Ishita Mostafa, Naila Nurun Nahar, Md Munirul Islam, Sayeeda Huq et al.
BACKGROUND: Childhood undernutrition remains a significant global health challenge accounting for over half of all under 5 child mortality. Moderate acute malnutrition (MAM), which leads to wasting [weight-for-length z-scores (WLZ) between - 2 and - 3], affects 33 million children under 5 globally a...
Ishita Mostafa, Matthew C. Hibberd, Steven J. Hartman, Md Hasan Hafizur Rahman et al.
BACKGROUND: Globally, stunting affects ∼150 million children under five, while wasting affects nearly 50 million. Current interventions have had limited effectiveness in ameliorating long-term sequelae of undernutrition including stunting, cognitive deficits and immune dysfunction. Disrupted develop...
Ishita Mostafa, Nurun Nahar Naila, Mustafa Mahfuz, Manoj Roy et al.
AIM: This study investigated the microbial quality of food and water consumed by children in four slums in Dhaka, the capital of Bangladesh, together with the associated risk factors. METHODS: This cross-sectional study took place from December 2015 to May 2016 and focused on 360 children under the ...
Ishita Mostafa, Shamin Fatema Islam, Prasenjit Mondal, Abu Syed Golam Faruque et al.
BACKGROUND: Vitamin A deficiency (VAD) is one of the most prevalent micronutrient deficiencies in the world. About 2% of all deaths among children under five years of age (U-5) are attributable to VAD. Currently evidence-based knowledge is grossly lacking about the factors associated with low covera...
Ishita Mostafa, Mahamudul Hasan, Subhasish Das, Soroar Hossain Khan et al.
OBJECTIVES: Malnutrition remains a major problem among adolescents worldwide, but the types of nutritional problem impacting this group are changing significantly. This study aims to describe and analyse the trends in nutritional status and related epidemiological characteristics of 10 to 19 years o...
Shoeb Bin Islam, Tahmeed Ahmed, Mustafa Mahfuz, Ishita Mostafa et al.
BACKGROUND: Persistent diarrhoea (PD) is poorly recognised and it requires proper assessment and early intervention to ensure effective treatment. The International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) has been managing children with PD for more than two decades. This review ...
Steven J. Hartman, Matthew C. Hibberd, Ishita Mostafa, Nurun Nahar Naila et al.
Globally, severe acute malnutrition (SAM), defined as a weight-for-length z -score more than three SDs below a reference mean (WLZ < −3), affects 14 million children under 5 years of age. Complete anthropometric recovery after standard, short-term interventions is rare, with children often left w...
Ishita Mostafa, Shah Mohammad Fahim, Subhasish Das, Md. Amran Gazi et al.
BACKGROUND: Childhood undernutrition is a major public health concern that needs special attention to achieve 2025 global nutrition targets. Moderate acute malnutrition (MAM), manifest as wasting (low weight-for-height), affects 33 million children under 5, yet there are currently no global guidelin...
Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, Subhasish Das et al.