Charge Diabetes Working Group, Dajiang J. Liu, VA Million Veteran Program, Gina M. Peloso et al.
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein ch...
Paolo Zanoni, Sumeet A. Khetarpal, Daniel B. Larach, William Hancock‐Cerutti et al.
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C l...
Georg Ehret, Teresa Ferreira, Daniel I. Chasman, Anne Jackson et al.
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 ...
Paul McKeigue, J. E. Ferrie, T. Pierpoint, Michael Marmot
BACKGROUND: Rates of coronary heart disease are higher in South Asians (Indians, Pakistanis, and Bangladeshis) settled overseas than in other ethnic groups. We tested the hypothesis that this excess risk results from metabolic disturbances associated with insulin resistance. METHODS AND RESULTS: The...
Maria Hughes, Olli Saarela, Jan Stritzke, Frank Kee et al.
BACKGROUND: More accurate coronary heart disease (CHD) prediction, specifically in middle-aged men, is needed to reduce the burden of disease more effectively. We hypothesised that a multilocus genetic risk score could refine CHD prediction beyond classic risk scores and obtain more precise risk est...
Linda J. Ferrier, Anthony S. Bashir, David L. Meryash, Jennifer L. Johnston et al.
SUMMARY The conversational skills of 18 individuals with fragile‐X syndrome (FXS) were compared with those of two other matched groups with autism and Down syndrome. The FXS group used more eliciting forms in conversation than those with Down syndrome, and also used partial self‐repetition more ofte...
Robert J. Smith, Leon Bennun, Thomas M. Brooks, Stuart H. M. Butchart et al.
Abstract Systematic conservation planning and Key Biodiversity Areas (KBAs) are the two most widely used approaches for identifying important sites for biodiversity. However, there is limited advice for conservation policy makers and practitioners on when and how they should be combined. Here we pro...
Augusto Di Castelnuovo, Simona Costanzo, Marialaura Bonaccio, Patrick McElduff et al.
AIM: To test the association of alcohol consumption with total and cause-specific mortality risk. DESIGN: Prospective observational multi-centre population-based study. SETTING: Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project. PARTICIPANTS: A t...
Myrtle Hill
Abstract Focusing on the archives of Irish Protestant missionary societies, this article aims to contribute to the growing feminist literature on a female missionary subculture which provided unique opportunities for women in the late nineteenth and early twentieth centuries. Stressing diversity of ...
Moreno Di Marco, Thomas M. Brooks, Annabelle Cuttelod, Lincoln Fishpool et al.
World governments have committed to increase the global protected areas coverage by 2020, but the effectiveness of this commitment for protecting biodiversity depends on where new protected areas are located. Threshold- and complementarity-based approaches have been independently used to identify im...
John Gregson, Daniel F. Freitag, Praveen Surendran, Nathan O. Stitziel et al.
is unlikely to be a causal risk factor.
David Leclère, Michael Obersteiner, Rob Alkemade, Rosamunde E. A. Almond et al.
Unless actions are taken to reduce multiple anthropogenic pressures, biodiversity is expected to continue declining at an alarming rate. Models and scenarios can be used to help design the pathways to sustain a thriving nature and its ability to contribute to people. This approach has so far been ha...
Abigail S. Golden, Roberta E. Weisbrod
Ferries and other passenger vessels provide a crucial mode of transportation for many in the developing world, especially in archipelagic nations like Indonesia and in river delta nations like Bangladesh. However, this dependence on passenger vessels coincides with a high rate of accidents and fatal...
Tim J. Veersema, Andrew de Neef, Jackelien van Scheppingen, Cyrille H. Ferrier et al.
Recent studies suggested a possible association between malformations of cortical development and microvascular density. In this study we aimed to further elucidate the relation between microvascular density and cortical developmental abnormalities in a cohort of 97 patients with epilepsy and histol...
Sudip Saha, A.H.M. Selim Reza, Mrinal Kanti Roy
The Tista River is a tributary of the Brahmaputra River. The deposits that exposed along the both banks of the Tista River are characterized mainly by sand, sand laden with gravel and pebble with minor amounts of silt and clay. The X-ray Diffraction (XRD) of the clay sized sediments of the Tista Riv...