Lorenz von Seidlein, Deok Ryun Kim, Mohammad Ali, Hyejon Lee et al.
BACKGROUND: The burden of shigellosis is greatest in resource-poor countries. Although this diarrheal disease has been thought to cause considerable morbidity and mortality in excess of 1,000,000 deaths globally per year, little recent data are available to guide intervention strategies in Asia. We ...
Marcelino Lucas, Jacqueline Deen, Lorenz von Seidlein, Xuan-Yi Wang et al.
BACKGROUND: New-generation, orally administered cholera vaccines offer the promise of improved control of cholera in sub-Saharan Africa. However, the high prevalence of human immunodeficiency virus (HIV) infection in many cholera-affected African populations has raised doubts about the level of prot...
Sujit Bhattacharya, Dipika Sur, Mohammad Ali, Suman Kanungo et al.
Background Efficacy and safety of a two-dose regimen of bivalent killed whole-cell oral cholera vaccine (Shantha Biotechnics, Hyderabad, India) to 3 years is established, but long-term efficacy is not. We aimed to assess protective efficacy up to 5 years in a slum area of Kolkata, India. Methods In ...
M. Ansaruzzaman, N. A. Bhuiyan, G. Balakrish Nair, David A. Sack et al.
To the Editor: Cholera outbreaks caused by toxigenic Vibrio cholerae serogroup O1 frequently occur in many sub-Saharan African countries. The serogroup O1 is classified into two biotypes, classical and El Tor. The seventh and current pandemic of cholera is caused by the El Tor biotype; the classical...
Dipika Sur, T. Ramamurthy, Jacqueline Deen, Sujit Bhattacharya
Infectious diseases kill about 11 million children each year while acute diarrhoeal diseases account for 3.1 million deaths in children under 5 yr of age, of which 6,00,000 deaths annually are contributed by shigellosis alone. Shigellosis, also known as acute bacillary dysentery, is characterized by...
M. Ansaruzzaman, Marcelino Lucas, Jacqueline Deen, N. A. Bhuiyan et al.
Forty-two episodes of Vibrio parahaemolyticus infections were detected in Beira, Mozambique, from January to May 2004. The majority of the isolates (81%) belonged to the pandemic serovars (O3:K6 and O4:K68) of V. parahaemolyticus. The pandemic serovars were positive by group-specific PCR (GS-PCR) an...
Xuanyi Wang, M. Ansaruzzaman, Raul Vaz, Catarina Mondlane et al.
BACKGROUND: Early detection of cholera outbreaks is crucial for the implementation of the most appropriate control strategies. METHODS: The performance of an immunochromatographic dipstick test (Institute Pasteur, Paris, France) specific for Vibrio cholerae O1 was evaluated in a prospective study in...
Sujit Bhattacharya, Robert E. Black, Lawrence L. Bourgeois, John D. Clemens et al.
Long-lasting cholera outbreaks in Africa suggest limitations in the current strategy of disease control.
Lorenz von Seidlein, Xuanyi Wang, Arminda Macuamule, Catarina Mondlane et al.
OBJECTIVE: As residents of sub-Saharan Africa are at high risk for HIV and cholera, it is biologically plausible that immune suppression caused by HIV infection predisposes to cholera. Our aim was to assess the potential association between both diseases. METHODS: We conducted a case-control study i...
M. Ansaruzzaman, N. A. Bhuiyan, Ashrafus Safa, Marzia Sultana et al.
Vibrio cholerae O1 strains that are hybrids between the classical and El Tor biotypes were isolated during two consecutive years (2004-2005) from diarrheal patients in Mozambique. Similar variants isolated in Bangladesh and recently isolated El Tor strains were analyzed for genetic diversity. Pulsed...
Mohammad Ali, Young Ae You, Dipika Sur, Suman Kanungo et al.
Background The test-negative design (TND) has emerged as a simple method for evaluating vaccine effectiveness (VE). Its utility for evaluating oral cholera vaccine (OCV) effectiveness is unknown. We examined this method's validity in assessing OCV effectiveness by comparing the results of TND analys...
Jacqueline Deen, John D. Clemens
Cholera is a disease of poverty and occurs where there is a lack of access to clean water and adequate sanitation. Since improved water supply and sanitation infrastructure cannot be implemented immediately in many high-risk areas, vaccination against cholera is an important additional tool for prev...
Jacqueline Deen, John D. Clemens
Vaccine herd protection is the extension of the defense conferred by immunization beyond the vaccinated to unvaccinated persons in a population, as well as the enhancement of the protection among the vaccinated, due to vaccination of the surrounding population. Vaccine herd protection has traditiona...
John D. Clemens, Jacqueline Deen, Firdausi Qadri
Inactivated oral cholera vaccines (OCVs) are a cornerstone of international efforts to control cholera, and are currently deployed from a global stockpile for the control of epidemics and endemic hotspots, as well as for humanitarian emergencies. One inactivated OCV (with tradenames Shanchol™ and Eu...
Adam C. Schneider, Marc J. Kuchner, Jacqueline K. Faherty, Aaron M. Meisner et al.
Abstract The Backyard Worlds: Planet 9 citizen science project uses data from the Wide-field Infrared Survey Explorer to detect infrared objects with significant motion. In this work, we present the majority of the L and T dwarf candidates discovered through this effort. For each candidate, we provi...