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Results for “"Jaishree Tripathi"”

3 results

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

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Lei Zhu, Jaishree Tripathi, Frances Rocamora, Olivo Miotto et al.

Journal: Nature CommunicationsYear: 2018Citations: 76

The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying artemisinin resistance, we reanalyze 773 P. falciparum isolates from TRACI-st...

Health SciencesMedicinePublic Health, Environmental and Occupational HealthOpen Access
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Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

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Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak et al.

Journal: Communications BiologyYear: 2022Citations: 74

The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P....

Health SciencesMedicinePublic Health, Environmental and Occupational HealthOpen Access
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The mechanism of artemisinin resistance of <i>Plasmodium falciparum</i> malaria parasites originates in their initial transcriptional response

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Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak et al.

Journal: bioRxiv (Cold Spring Harbor Laboratory)Year: 2021Citations: 1

Abstract The emergence and spread of artemisinin resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria eliminations ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducte...

Health SciencesMedicinePublic Health, Environmental and Occupational HealthOpen Access
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