Julie M. Long, Prasenjit Mondal, Jamie Westcott, Leland V. Miller et al.
Background: Environmental enteric dysfunction (EED), a chronic inflammatory disorder of the small bowel, is suspected to impair absorption of micronutrients, including zinc. Objective: The objective of this study was to compare zinc absorption from micronutrient powder (MNP) over a range of zinc dos...
M Munirul Islam, Robert E. Black, Nancy F. Krebs, Jamie Westcott et al.
Background Children in resource-limited settings remain vulnerable to zinc deficiency and its consequences. Objectives To evaluate the effects of different doses, durations, and frequencies of zinc supplementation on the incidence of diarrhea and change in linear growth among young children. Methods...
Md Saidul Islam, Christine M. McDonald, Nancy F. Krebs, Jamie Westcott et al.
Zinc is essential to supporting growth in young children especially for tissues undergoing rapid cellular differentiation and turnover, such as those in the immune system and gastrointestinal tract. Therapeutic zinc supplementation has been initiated in low-income countries as part of diarrhea treat...
Waldemar A. Carlo, Alan Tita, Janet Moore, Musaku Mwenechanya et al.
BACKGROUND: In 2023, the Azithromycin Prevention in Labor Use (A-PLUS) trial showed intrapartum azithromycin reduces maternal sepsis or death in women with planned vaginal delivery in low-resource settings, but whether it reduces maternal infection is unknown. We aimed to evaluate the effectiveness ...
Prasenjit Mondal, Julie M. Long, Jamie Westcott, M Munirul Islam et al.
OBJECTIVES: Environmental enteric dysfunction (EED) impairs zinc absorption from food, and zinc deficiency may contribute to the poor growth associated with EED. We examined zinc absorption from a standardized aqueous zinc dose, and habitual daily endogenous fecal zinc excretion (EFZ) and compared t...
M Munirul Islam, Robert E. Black, Nancy F. Krebs, Jamie Westcott et al.
Young children in resource-constrained settings are susceptible to zinc deficiency and its deleterious health effects. The objective of this secondary analysis was to evaluate the effects of the following six interventions on biomarkers of iron and zinc status among a subgroup of young children in D...
Julie M. Long, Afsana Mim Khandaker, Rahvia Alam Sthity, Jamie Westcott et al.
A sensitive and reliable biomarker of zinc status has yet to be identified, but observational research suggests that the exchangeable zinc pool (EZP) size may be a possible biomarker. This randomized, placebo-controlled trial aimed to compare the change in EZP size from baseline to endline in 174 ch...
Thomas J. Hayman, Peter F. Hickey, Daniela Amann‐Zalcenstein, Cavan Bennett et al.
Preventive zinc supplementation provided as a stand-alone dispersible tablet, or via home fortification as multiple micronutrient powders (MNPs), has been considered a potential strategy to prevent zinc deficiency and improve health (including immune) outcomes among children in low- and middle-incom...
Meryl E. Wastney, Julie M. Long, Christine M. McDonald, Nancy F. Krebs et al.
OBJECTIVES: Stunting [length-for-age z score (LAZ) <-2] has multiple causes and is prevalent in areas with low dietary zinc (Zn) intake. Zinc kinetics from non-stunted infants were used in a published model for predicting linear growth; here, we directly measure zinc kinetics in stunted infants. ...
Nancy F. Krebs, Julie M. Long, Prasenjit Mondal, Jamie Westcott et al.
Objective EED has been suspected to impair absorption of micronutrients, including Zn, due to the abnormal small bowel mucosa. MNP interventions with 5 mg/sachet have generally not impacted Zn‐associated outcomes. The objective of this study was to compare Zn absorption across a wide range of MNP Zn...
M.Munirul Islam, Leslie R. Woodhouse, Jamie Westcott, Rahvia Alam Sthity et al.
BACKGROUND: Previous studies showed total absorbed zinc (TAZ) was comparable in diets containing a higher zinc rice variety or conventional rice variety (Lo-Zn CR). This study compared TAZ in a polished zinc-biofortified rice (Hi-Zn BfR) compared with Lo-Zn CR. OBJECTIVE: To measure the amount of TA...
Lauren Thompson, Charles D. Arnold, Janet M Peerson, Julie M. Long et al.
In Bangladesh, anaemia is estimated to affect 52% of children 6-59 months, with the youngest children (6-23 months) experiencing the highest levels of anaemia (71%). Micronutrient powders (MNPs) are designed to increase micronutrient intake in young children; however, in some settings, the prevalenc...
Leland V. Miller, Julie M. Long, Prasenjit Mondal, Jamie Westcott et al.
The effect of infection and inflammation on EZP size, a putative biomarker of Zn status, is unknown. We sought to evaluate the relationship of EZP to systemic inflammation in a group of toddlers with high risk of Zn deficiency and EED. Subjects were 112 children from an urban slum area in Dhaka, Ban...
Meryl E. Wastney, Julie M. Long, Christine M. McDonald, Nancy F. Krebs et al.
This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Pediatric Gastroenterology & Nutrition. The published version of record [Zinc Kinetics Correlate With Length-for-Age z Scores in Bangladeshi Infants. Journal of Pediatric Gastroenterology &...
Meryl E. Wastney, Julie M. Long, Christine M. McDonald, Nancy F. Krebs et al.
This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Pediatric Gastroenterology & Nutrition. The published version of record [Zinc Kinetics Correlate With Length-for-Age z Scores in Bangladeshi Infants. Journal of Pediatric Gastroenterology &...
Nurun Nahar Naila, Subhasish Das, Afsana Mim Khandaker, Rahvia Alam et al.
Background: Fortification of rice with slaked lime is an acceptable and inexpensive way to combat calcium (Ca) deficiency. However, bioavailability of calcium after intake of slaked lime fortified rice is yet to be investigated. Objective: To measure the fractional absorption of Ca (FAC) from slaked...