Claire Palles, Laura Chegwidden, Xinzhong Li, John M. Findlay et al.
BACKGROUND & AIMS: Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subse...
Debasish Das, Savid Ishaq, Rebecca Harrison, Kiran Kosuri et al.
OBJECTIVES: To assess the variation in practice of Barrett's esophagus (BE) management in comparison with accepted international guidelines before and after the introduction of a large BE randomized controlled trial (RCT) with protocols including those of tissue sampling. DESIGN: A validated anonymi...
Janusz Jankowski, Sharon Love, Gavin Reilly, John de Caestecker et al.
<h3>Introduction</h3> We prescribe medicines to patients but the key factor determining efficacy is the dose taken. Recent evidence suggests compliance with aspirin therapy is vital to ensuring its chemoprevention efficacy. Therefore we look at the patient’s compliance with aspirin in a large trial....
Sharon Love, Gavin Reilly, Corran Roberts, Paul Moayyedi et al.
<h3>Introduction</h3> From 2005 to 2011 two large UK studies recruited 6,327 evaluable patients with Barrett’s Oesophagus attending hospital clinics. Baseline clinical, patient history and quality of life data was collected prior to randomisation and this rich dataset is the basis for this abstract....