Fatima Zohra Mokhfi, Md. Al Amin, Mehrukh Zehravi, Sherouk Hussein Sweilam et al.
This review aims to summarize the role of alkaloids as potential modulators of the PI3K/Akt/mTOR (PAMT) pathway in cancer therapy. The PAMT pathway plays a critical role in cell growth, survival, and metabolism, and its dysregulation contributes to cancer hallmarks. In healthy cells, this pathway is...
Biswajit Kumar Utpal, Fatima Zohra Mokhfi, Mehrukh Zehravi, Sherouk Hussein Sweilam et al.
Neurological diseases (NDs), including neurodegenerative disorders and acute injuries, are a significant global health concern. The PI3K/Akt/mTOR pathway, a crucial signaling cascade, is responsible for the survival of cells, proliferation, and metabolism. Dysregulation of this pathway has been link...
Md. Rezaul Islam, Md Al-Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam et al.
BACKGROUND: Neurodegenerative diseases (NDs), including Alzheimer's disease, Parkinson's disease, and Huntington's disease, are complex and challenging due to their intricate pathophysiology and limited treatment options. METHODS: This review systematically sourced articles related to neurodegenerat...
Biswajit Kumar Utpal, Md. Al Amin, Mehrukh Zehravi, Sherouk Hussein Sweilam et al.
Neurodegeneration is the progressive loss of neurons that results in neurodegenerative diseases (NDs). Currently, there are few effective treatments for NDs, such as Alzheimer's disease, Parkinson's disease, Multiple sclerosis, and Huntington's disease, which involve gradual neuronal death and cogni...
Md. Faysal, Md. Al Amin, Mehrukh Zehravi, Sherouk Hussein Sweilam et al.
Flavonoids in fruits, vegetables, and plant-based drinks have potential neuroprotective properties, with clinical research focusing on their role in reducing oxidative stress, controlling inflammation, and preventing apoptosis. Some flavonoids, such as quercetin, kaempferol, fisetin, apigenin, luteo...
Trupti Pratik Durgawale, Varikalla Rajashakar, Jeetendra Kumar Gupta, Shanaz Banu et al.
Maternal embryonic leucine zipper kinase (MELK), a pivotal signaling protein, plays a crucial role in various physiological processes, such as cell growth, survival, and differentiation. There is currently a growing interest in MELK as a promising therapeutic target for multiple cancers, including t...
Md Zamshed Alam Begh, Jishan Khan, Md. Al Amin, Sherouk Hussein Sweilam et al.
Monoterpenoids, compounds found in various organisms, have diverse applications in various industries. Their effectiveness is influenced by the oil's chemical composition, which in turn is influenced by plant genotype, environmental conditions, cultivation practices, and plant development stage. The...
Md. Rezaul Islam, Abdur Rauf, Shopnil Akash, Ajoy Kumer et al.
Kuldeep Singh, Divya Jain, Pranshul Sethi, Jeetendra Kumar Gupta et al.
Gene therapy offers a revolutionary approach for treating genetic and acquired disorders by delivering therapeutic genes to target cells. Viral vectors, engineered for efficient gene delivery, have become indispensable due to their high transduction efficiency, enhanced targeting specificity, and mi...
Sumon Roy, Sajib Chandra Roy, Mehrukh Zehravi, Sherouk Hussein Sweilam et al.
The increasing incidence of neurodegenerative diseases (NDs) and the constraints of existing treatment methods have spurred a keen interest in investigating alternative therapies. Medicinal plants, renowned for their long-standing use in traditional medicine, offer a hopeful avenue for discovering n...
B. M. Redwan Matin Zidan, Mehrukh Zehravi, Shaik Kareemulla, Kallam Sudha Divya Madhuri et al.
Acute mountain sickness (AMS), high-altitude pulmonary edema (HAPE), and high-altitude cerebral edema (HACE) are three common forms of altitude sickness. These conditions can be life-threatening, with symptoms like fatigue, dizziness, and headaches. Ascending to high elevations increases the likelih...
Md. Faysal, Mehrukh Zehravi, Md. Al Amin, Safia Obaidur Rab et al.
Chronic neurologic and psychiatric diseases such as schizophrenia, depression, Parkinson's, and Alzheimer's are increasingly linked to infectious microorganisms and gut microbiota. This review explores how pathogenic microorganisms and microbial communities impact neuropsychiatric, neurodegenerative...
Md. Al Amin, Talha Bin Emran, Jishan Khan, Mehrukh Zehravi et al.
Cancer is the leading cause of morbidity and mortality in people throughout the world. There are many signaling pathways associated with cancerous diseases, from which the Mitogen-activated protein kinase (MAPK) pathway performs a significant role in this regard. Apoptosis and proliferation are corr...
Md. Rezaul Islam, Puja Sutro Dhar, Shopnil Akash, Sabeena Hussain Syed et al.
Hypertension (HTN), a complex cardiovascular disease (CVD), significantly impacts global health, prompting a growing interest in complementary and alternative therapeutic approaches. This review article seeks to provide an up-to-date and thorough summary of modern therapeutic techniques for treating...
Mehrukh Zehravi, Sharuk L. Khan, Jeetendra Kumar Gupta, Patibandla Jahnavi et al.
Oral drug delivery remains the most popular method due to its patient compliance, affordability, and ease of use. The effective administration of therapeutic medicines faces physiological challenges such as enzymatic degradation, low permeability, and inadequate bioavailability. Polymeric nanopartic...