Ahlam Abuawad, Jeff Goldsmith, Julie B. Herbstman, Faruque Parvez et al.
Urinary As (uAs) is a biomarker of As exposure. Urinary creatinine (uCr) or specific gravity (SG) are used to correct uAs for urine dilution. However, uCr is correlated with As methylation, whereas SG has limitations in individuals with kidney damage. We aimed to evaluate which urine dilution correc...
Ahlam Abuawad, Anne K. Bozack, Ana Navas‐Acién, Jeff Goldsmith et al.
Background: Chronic arsenic (As) exposure is a global environmental health issue. Inorganic As (InAs) undergoes methylation to monomethyl (MMAs) and dimethyl-arsenical species (DMAs); full methylation to DMAs facilitates urinary excretion and is associated with reduced risk for As-related health out...
Haotian Wu, Vrinda Kalia, Megan M. Niedzwiecki, Marianthi‐Anna Kioumourtzoglou et al.
Chronic exposure to arsenic (As) remains a global public health concern and our understanding of the biological mechanisms underlying the adverse effects of As exposure remains incomplete. Here, we used a high-resolution metabolomics approach to examine how As affects metabolic pathways in humans. W...
Irene Martínez-Morata, Faruque Parvez, Haotian Wu, Mahbubul Eunus et al.
BACKGROUND: Inorganic arsenic is metabolized to monomethyl- (MMAs) and dimethyl- (DMAs) species via one-carbon metabolism (OCM); this facilitates urinary arsenic elimination. OCM is influenced by folate and vitamin B12 and previous randomized control trials (RCTs) showed that folic acid (FA) supplem...
Wending Li, Haotian Wu, Jeff Goldsmith, Ronald A. Glabonjat et al.
Arsenic exposure remains a leading public health concern. Folic acid (FA) supplementation enhances one-carbon metabolism (OCM), thus promoting arsenic methylation and facilitating urinary arsenic elimination. Here, we investigate the metabolic profiles linked to arsenic exposure and metabolism based...
Haotian Wu, Vrinda Kalia, Megan M. Niedzwiecki, Marianthi-Anna Kioumourtzoglu et al.
Our understanding of the pathways underlying the effects of arsenic (As) remains incomplete, in part because studies historically focused on individual targets. High-resolution metabolomics can capture changes more proximal to disease and integrates changes in multiple regulatory processes, providin...
Ahlam Abuawad, Anne K. Bozack, Ana Navas‐Acién, Jeff Goldsmith et al.
Background and Aim. Arsenic exposure is a global issue. Inorganic As (InAs) undergoes methylation to monomethyl (MMAs) and dimethyl-arsenical species (DMAs); full methylation to DMAs facilitates urinary excretion and can reduce risk of adverse health outcomes. Folate and creatine influence one-carbo...
Irene Martinez Morata, Haotian Wu, Faruque Parvez, Mahbubul Eunus et al.
BACKGROUND AND AIM: Inorganic arsenic (iAs) is metabolized to less toxic mono- (MMA) and dimethyl- (DMA) species via one-carbon metabolism (OCM). OCM is driven by folate and B12 and previous randomized control trials (RCTs) showed that that folic acid (FA) supplementation increases arsenic methylati...
Julie L. Ozanne, Brennan Davis, Jeff B. Murray, Sonya A. Grier et al.
Marketing and policy researchers aiming to increase the societal impact of their scholarship should engage directly with relevant stakeholders. For maximum societal effect, this engagement needs to occur both within the research process and throughout the complex process of knowledge transfer. The a...
Lawrence Angus is Professor is Head of the School of Education at the University of Ballarat. His most recent book (with Professor Terri Seddon of Monash University) is Reshaping Australian Education: Beyond Nostalgia. His publications include several books over 50 refereed book chapters and article...