Jieyu Qi, Liyan Zhang, Ling Lü, Fangzhi Tan et al.
Gene therapy for congenital deafness has shown promising results in children but lacks data in older populations. We conducted a single-arm trial of adeno-associated virus (AAV)-OTOF gene therapy using the Anc80L65 capsid in ten participants with autosomal recessive deafness 9 aged 1.5 to 23.9 years...
Xiangyu Ma, Li-Nan Chen, Menghui Liao, Liyan Zhang et al.
The class C orphan G-protein-coupled receptor (GPCR) GPR156, which lacks the large extracellular region, plays a pivotal role in auditory function through Gi2/3. Here, we firstly demonstrate that GPR156 with high constitutive activity is essential for maintaining auditory function, and further revea...
Siwei Guo, Jieying Cao, Guodong Hong, Yuning Song et al.
Age-related hearing loss (ARHL) is among the most prevalent and complex disorders in older adults. However, the pathogenesis of ARHL remains poorly understood. Using a single-cell transcriptomic landscape of mouse cochlea at five time points (1, 2, 5, 12 and 15 months), we found that the levels of h...
Qingkong Chen, Jieyu Xia, Fengjun Liu, Jianping Fan et al.
This study developed a novel heterogeneous Vis-Photo+Fenton-like system by integrating visible-light-responsive Co3O4/TiO2 photocatalysis with peroxymonosulfate (PMS) activation for efficient atrazine (ATZ) degradation. The synergistic process achieved complete ATZ removal within 60 min under near-n...
Nianci Li, Ziyu Zhang, Liyan Zhang, Danqi Wu et al.
platform for investigating the pathogenesis of deafness and exploring therapeutic approaches. However, the widely used commercial Matrigel in cochlear organoid culture suffers from issues related to consistency and structural stability. Here, we developed a cochlear organoid culture system using syn...
Man Wang, Ziyu Zhang, Xiaohan Wang, Liyan Zhang et al.
Genetic mutations cause hereditary deafness, in which mutations in the POU4 transcription factor 3 gene (POU4F3) lead to autosomal dominant non-syndromic deafness 15 (DFNA15), for which no effective clinical treatment currently exists. Gene editing holds promise for precisely repairing mutated nucle...
Man Wang, Bei Wang, Minhao Yang, Fangzhi Tan et al.
Hereditary deafness represents a significant global health challenge with limited therapeutic interventions. Most cases are caused by monogenic mutations inherited in an autosomal dominant or recessive manner, making them suitable targets for gene editing therapies. Recent advances in gene editing t...
Xin Chen, Yuwei Che, Jieyu Qi, Ming Cen et al.
Unraveling the intricate composition and function of the cochlea is paramount to comprehending the mechanisms underlying sound perception and the pathogenesis of auditory disorders. The mammalian cochlea displays a highly organized structure, which contributes to the diversity and complexity of audi...