Mohammad H. Forouzanfar, Ashkan Afshin, Lily Alexander, H Ross Anderson et al.
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debat...
Karen L. Kotloff, James P. Nataro, William C. Blackwelder, Dilruba Nasrin et al.
Background Diarrhoeal diseases cause illness and death among children younger than 5 years in low-income countries. We designed the Global Enteric Multicenter Study (GEMS) to identify the aetiology and population-based burden of paediatric diarrhoeal disease in sub-Saharan Africa and south Asia. Met...
Salim Yusuf, Philip Joseph, Sumathy Rangarajan, Shofiqul Islam et al.
Background: Global estimates of the impact of common modifiable risk factors on cardiovascular disease (CVD) and mortality are largely based on data from separate studies, using different methodologies. The Prospective Urban Rural Epidemiology (PURE) study overcomes these limitations by using simila...
Fatimah S. Dawood, A. Danielle Iuliano, Carrie Reed, Martin I. Meltzer et al.
Background 18,500 laboratory-confirmed deaths caused by the 2009 pandemic influenza A H1N1 were reported worldwide for the period April, 2009, to August, 2010. This number is likely to be only a fraction of the true number of the deaths associated with 2009 pandemic influenza A H1N1. We aimed to est...
Monika Böhm, Ben Collen, Jonathan Baillie, Philip Bowles et al.
Effective and targeted conservation action requires detailed information about species, their distribution, systematics and ecology as well as the distribution of threat processes which affect them. Knowledge of reptilian diversity remains surprisingly disparate, and innovative means of gaining rapi...
Jie Liu, James A Platts-Mills, Jane Juma, Furqan Kabir et al.
Background Diarrhoea is the second leading cause of mortality in children worldwide, but establishing the cause can be complicated by diverse diagnostic approaches and varying test characteristics. We used quantitative molecular diagnostic methods to reassess causes of diarrhoea in the Global Enteri...
Saifur Rahman Chowdhury, Dipak Chandra Das, Tachlima Chowdhury Sunna, Joseph Beyene et al.
Background: Knowing the prevalence of multimorbidity among adults across continents is a crucial piece of information for achieving Sustainable Development Goal 3.4, which calls for reducing premature death due to non-communicable diseases. A high prevalence of multimorbidity indicates high mortalit...
Gilles R. Dagenais, Darryl P. Leong, Sumathy Rangarajan, Fernando Laņas et al.
BACKGROUND To our knowledge, no previous study has prospectively documented the incidence of common diseases and related mortality in high-income countries (HICs), middle-income countries (MICs), and low-income countries (LICs) with standardised approaches. Such information is key to developing glob...
Luca Pagani, Daniel J. Lawson, Evelyn Jagoda, Alexander Mörseburg et al.
High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for infe...
David F. Choy, Kevin M. Hart, Lee A. Borthwick, Aarti Shikotra et al.
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n = 51), endobronchial tissue gene expression analysis revealed three major patient clusters: TH2-high, TH17-high, and TH2/17...
Mihai Pop, Alan W. Walker, Joseph N. Paulson, Brianna Lindsay et al.
BACKGROUND: Diarrheal diseases continue to contribute significantly to morbidity and mortality in infants and young children in developing countries. There is an urgent need to better understand the contributions of novel, potentially uncultured, diarrheal pathogens to severe diarrheal disease, as w...
Gregory A. Roth, Catherine O. Johnson, Kalkidan Hassen Abate, Foad Abd-Allah et al.
Importance: Cardiovascular disease (CVD) is the leading cause of death in the United States, but regional variation within the United States is large. Comparable and consistent state-level measures of total CVD burden and risk factors have not been produced previously. Objective: To quantify and des...
Daniel P. Donnelly, Catherine M. Rawlins, Caroline J. DeHart, Luca Fornelli et al.
One gene can give rise to many functionally distinct proteoforms, each of which has a characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact proteins and proteoforms. Here members of the Consortium for Top-Down Proteomics provide a decision tree that guides research...
Kathryn E. Lafond, Harish Nair, Mohammad Hafiz Rasooly, Fátima Valente et al.
BACKGROUND: The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has be...
Marjan Walli-Attaei, Philip Joseph, Annika Rosengren, Clara K Chow et al.
BACKGROUND Some studies, mainly from high-income countries (HICs), report that women receive less care (investigations and treatments) for cardiovascular disease than do men and might have a higher risk of death. However, very few studies systematically report risk factors, use of primary or seconda...