Arjen M. Dondorp, Can İnce, Prakaykaew Charunwatthana, Josh Hanson et al.
BACKGROUND: This study sought to describe and quantify microcirculatory changes in the mucosal surfaces of patients with severe malaria, by direct in vivo observation using orthogonal polarization spectral (OPS) imaging. METHODS: The microcirculation in the rectal mucosa of adult patients with sever...
Louise T. Day, Harriet Ruysen, Vladimir Sergeevich Gordeev, Georgia R. Gore‐Langton et al.
BACKGROUND: - Birth Indicators Research Tracking in Hospitals (EN-BIRTH) study aims to validate selected newborn and maternal indicators for routine tracking of coverage and quality of facility-based care for use at district, national and global levels. METHODS: EN-BIRTH is an observational study in...
Josh Hanson, Sue J. Lee, Sanjib Mohanty, M. Abul Faiz et al.
BACKGROUND: World Health Organization treatment guidelines recommend that adults with severe malaria be admitted to an intensive care unit (ICU). However, ICU facilities are limited in the resource-poor settings where most malaria occurs. Identification of patients at greater risk of complications m...
Louise T. Day, Qazi Sadeq-ur Rahman, Ahmed Ehsanur Rahman, Nahya Salim et al.
BACKGROUND: Progress in reducing maternal and neonatal deaths and stillbirths is impeded by data gaps, especially regarding coverage and quality of care in hospitals. We aimed to assess the validity of indicators of maternal and newborn health-care coverage around the time of birth in survey data an...
Josh Hanson, Sophia WK Lam, Sanjib Mohanty, Shamshul Alam et al.
OBJECTIVE: To evaluate the efficacy and safety of liberal fluid resuscitation of adults with severe malaria. DESIGN, SETTING, PATIENTS, AND METHODS: Twenty-eight Bangladeshi and Indian adults with severe falciparum malaria received crystalloid resuscitation guided by transpulmonary thermodilution (P...
Josh Hanson, Sue J. Lee, Md Amir Hossain, Nicholas M. Anstey et al.
BACKGROUND: Microvascular obstruction and endothelial dysfunction have both been linked to tissue hypoperfusion in falciparum malaria, but their relative contributions to the disease's pathogenesis and outcome are unknown. METHODS: Microvascular blood flow was quantified in adults with severe falcip...
Josh Hanson, Sophia WK Lam, Kishore C Mahanta, Ritesh Pattnaik et al.
BACKGROUND: Sequestration of parasitized erythrocytes in the microcirculation is considered the central pathophysiological process in severe falciparum malaria. Hypovolemia with reduced oxygen delivery and microvascular obstruction have different implications for patient management; however, their r...
Katherine Plewes, A. A. N. M. Royakkers, Josh Hanson, Md Mahtab Uddin Hasan et al.
BACKGROUND: Acute kidney injury (AKI) complicating severe Plasmodium falciparum malaria occurs in up to 40% of adult patients. The case fatality rate reaches 75% in the absence of renal replacement therapy (RRT). The precise pathophysiology of AKI in falciparum malaria remains unclear. Histopatholog...
Josh Hanson, Nguyen Hoan Phu, Mahtab Uddin Hasan, Prakaykaew Charunwatthana et al.
BACKGROUND: Thrombocytopenia is a common finding in adults with severe falciparum malaria, but its clinical and prognostic utility is incompletely defined. METHODS: Clinical and laboratory data from 647 adults with severe falciparum malaria were analysed retrospectively to determine the relationship...
Richard J. Maude, Kamolrat Silamut, Katherine Plewes, Prakaykaew Charunwatthana et al.
BACKGROUND: Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated f...
Josh Hanson, Sue J. Lee, Sanjib Mohanty, Maryam Faiz et al.
BACKGROUND: Most adults dying from falciparum malaria will die within 48 hours of their hospitalisation. An essential component of early supportive care is the rapid identification of patients at greatest risk. In resource-poor settings, where most patients with falciparum malaria are managed, decis...
Richard J. Maude, Katherine Plewes, Muneeb Faiz, Josh Hanson et al.
Several antimalarials can cause significant prolongation of the electrocardiograph QT interval, which can be associated with an increased risk of potentially lethal ventricular arrhythmias. High doses of artemether and artemotil have been associated with QT prolongation in dogs, raising the possibil...
Josh Hanson, Amir Hossain, Prakaykaew Charunwatthana, Mahtab Uddin Hassan et al.
Although hyponatremia occurs in most patients with severe malaria, its pathogenesis, prognostic significance, and optimal management have not been established. Clinical and biochemical data were prospectively collected from 171 consecutive Bangladeshi adults with severe malaria. On admission, 57% of...
Atthanee Jeeyapant, Hugh W. F. Kingston, Katherine Plewes, Richard J. Maude et al.
BACKGROUND: Clinical trials in severe falciparum malaria require a large sample size to detect clinically meaningful differences in mortality. This means few interventions can be evaluated at any time. Using a validated surrogate endpoint for mortality would provide a useful alternative allowing a s...
Josh Hanson, Amir Hossain, Prakaykaew Charunwatthana, Mahtab Uddin Hassan et al.
Although hyponatremia occurs in most patients with severe malaria, its pathogenesis, prognostic significance, and optimal management have not been established. Clinical and biochemical data were prospectively collected from 171 consecutive Bangladeshi adults with severe malaria. On admission, 57% of...