Qifang Bi, Eva Ferreras, Lorenzo Pezzoli, Dominique Legros et al.
BACKGROUND: Killed whole-cell oral cholera vaccines (kOCVs) are becoming a standard cholera control and prevention tool. However, vaccine efficacy and direct effectiveness estimates have varied, with differences in study design, location, follow-up duration, and vaccine composition posing challenges...
Meagan Harper, Hebah Mejbel, Dylan Longert, Robin Abell et al.
Abstract Freshwater biodiversity is declining at an unprecedented rate. Freshwater conservationists and environmental managers have enough evidence to demonstrate that action must not be delayed but have insufficient evidence to identify those actions that will be most effective in reversing the cur...
Firdausi Qadri, Mohammad Ali, Julia Lynch, Fahima Chowdhury et al.
BACKGROUND: A single-dose regimen of inactivated whole-cell oral cholera vaccine (OCV) is attractive because it reduces logistical challenges for vaccination and could enable more people to be vaccinated. Previously, we reported the efficacy of a single dose of an OCV vaccine during the 6 months fol...
Marjolein J.A. Weerts, Kristina Lanko, Francisco J. Guzmán‐Vega, Adam Jackson et al.
PURPOSE: Pathogenic variants in SETD1B have been associated with a syndromic neurodevelopmental disorder including intellectual disability, language delay, and seizures. To date, clinical features have been described for 11 patients with (likely) pathogenic SETD1B sequence variants. This study aims ...
Brad K. Blitz, Maureen Lynch
Contents: 1. Statelessness and the Deprivation of Nationality Brad K. Blitz and Maureen Lynch 2. Nationality and Rights Laura van Waas 3. Citizenship in Kenya: The Nubian Case Abraham Korir Sing'Oei 4. From Erased and Excluded to Active Participants in Slovenia Jelka Zorn 5. From Statelessness to Ci...
Edward Jacobs, Brian D. Earp, Paul S. Appelbaum, Lori Bruce et al.
The first Hopkins-Oxford Psychedelic Ethics (HOPE) workshop convened to discuss ethical matters relating to psychedelics in August 2023 at the University of Oxford.<br/><br/>The organizers (BDE, DBY, EJ) aimed for a diversity of participant backgrounds and perspectives. The keynotes were given by an...
Andrew S. Azman, Iza Ciglenečki, Joseph Francis Wamala, Julia Lynch et al.
Hepatitis E virus (HEV) is a major cause of acute jaundice worldwide, with a case fatality risk (CFR) as high as 30% among symptomatic pregnant women. Human HEV includes four genotypes; the nonepidemic, zoonotic genotypes (typically 3 and 4) have gained increasing recognition in North America and Eu...
Mesbah Uddin Ahmed, Mario Baquilod, Claudio Deola, Nguyen Dong Tu et al.
Cholera remains a major public health problem in many countries. Poor sanitation and inappropriate clean water supply, insufficient health literacy and community mobilization, absence of national plans and cross-border collaborations are major factors impeding optimal control of cholera in endemic c...
Fahima Chowdhury, Taufiqur Rahman Bhuiyan, Afroza Akter, Md Saruar Bhuiyan et al.
We have earlier reported that a single dose of oral cholera vaccine (OCV) is protective in adults and children ≥5 years of age and sustained for 2 years. We enrolled participants (n = 240) from this study, between March-September 2017, over 3 years after receiving a primary single dose. Immune respo...
Suhi Jeon, Meagan Kelly, Jeesun Yun, Byungman Lee et al.
There is a need to develop cholera vaccines that are protective in young children under 5 years of age, which induce long-term immunity, and which can be incorporated into the Expanded Programme of Immunization (EPI) in cholera-endemic countries. The degree of protection afforded by currently availa...
Fahima Chowdhury, Afroza Akter, Taufiqur Rahman Bhuiyan, Imam Tauheed et al.
Bangladesh remains cholera endemic with biannual seasonal peaks causing epidemics. At least 300,000 severe cases and over 4,500 deaths occur each year. The available oral cholera vaccineshave not yet been adopted for cholera control in Bangladesh due to insufficient number of doses available for end...
Ashraful Islam Khan, Mohammad Ali, Julia Lynch, Alamgir Kabir et al.
BACKGROUND: Cholera increases the risk of harmful effects on foetuses. We prospectively followed pregnant women unaware of their pregnancy status who received a study agent in a clinical trial evaluating the association between exposure to an oral cholera vaccine (OCV) and foetal survival. METHODS: ...
Dana Cordell, BJ Jacobs, Aine Anderson, Miller Alonso Camargo‐Valero et al.
This report sets out the UK’s first comprehensive national phosphorus transformation strategy, based on extensive stakeholder consultation across the UK food system, in addition to economic modelling and biophysical analyses. The UK’s food system is in transition, driven in part by major changes to ...
Qiu T. Ruan, William B. Lynch, Rebecca H. Cole, Michael A. Rieger et al.
ABSTRACT Methamphetamine addiction remains a major public health concern in the United States that has paralleled the opioid epidemic. Psychostimulant use disorders have a heritable genetic component that remains unexplained. Methamphetamine targets membrane and vesicular transporters to increase sy...
Meagan Kelly, Suhi Jeon, Jeesun Yun, Byungman Lee et al.
There is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 co...