Jüergen Kreyling, Jürgen Dengler, Julia Walter, Nikolay Velev et al.
Biodiversity can buffer ecosystem functioning against extreme climatic events, but few experiments have explicitly tested this. Here, we present the first multisite biodiversity × drought manipulation experiment to examine drought resistance and recovery at five temperate and Mediterranean grassland...
Uzma Z. Rizvi
Abstract Acknowledgement I would like to thank my colleagues and friends Praveena Gullapalli and Benjamin Porter for the comments and insights that have helped shaped this piece in its initial stages. Additionally, this work has benefited from my conversations with Sandra Scham. I would also like to...
Jüergen Kreyling, Mohammed Abu Sayed Arfin Khan, Fahmida Sultana, W. Babel et al.
Extreme drought events challenge ecosystem functioning. Ecological response to drought is studied worldwide in a growing number of field experiments by rain-out shelters. Yet, few meta-analyses face severe challenges in the comparability of studies. This is partly because build-up of drought stress ...
David G. Walker, Horace R. Williams, Stephen P Kane, Joel Mawdsley et al.
OBJECTIVES: The incidence and prevalence of inflammatory bowel disease (IBD) is increasing throughout Asia. Since the 1950s, there has been substantial migration from South Asia (India, Pakistan, and Bangladesh) to the United Kingdom. The aim of this study was to define the clinical phenotype of IBD...
Sam Hodgson, Alice Williamson, Margherita Bigossi, Daniel Stow et al.
Abstract South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass index (BMI). However, reasons for this are poorly understood because genetic research is largely focused on European ancestry groups. We used recently derived multi-ancestry partitioned polygenic scores...
Benjamin M. Jacobs, Daniel Stow, Sam Hodgson, Julia Zöllner et al.
Abstract Understanding the genetic basis of routinely-acquired blood tests can provide insights into several aspects of human physiology. We report a genome-wide association study of 42 quantitative blood test traits defined using Electronic Healthcare Records (EHRs) of ~50,000 British Bangladeshi a...
Julia Zöllner, Sarah Finer, Kenneth J. Linton, Shaheen Akhtar et al.
This study assessed the contribution of five genes previously known to be involved in cholestatic liver disease in British Bangladeshi and Pakistani people. Five genes (ABCB4, ABCB11, ATP8B1, NR1H4, TJP2) were interrogated by exome sequencing data of 5236 volunteers. Included were non-synonymous or ...
Julia Zöllner, Binur Orazumbekova, Sam Hodgson, David A. van Heel et al.
British Pakistani and Bangladeshi (BPB) women have disproportionately high rates of gestational diabetes mellitus (GDM), with prevalence estimates up to three times higher than in the general population. They are also at increased risk of progressing to type 2 diabetes, leading to significant health...
Yihe Weng, Johann Kruschwitz, Laura M. Rueda‐Delgado, Kathy Ruddy et al.
Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early adulthood. Previous studies were predominantly cross-sectional or under-powered and could not indicate if impairment in sustained attention was a predictor of substance use o...
Yihe Weng, Johann Kruschwitz, Laura M. Rueda‐Delgado, Kathy Ruddy et al.
Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early adulthood. Previous studies were predominantly cross-sectional or under-powered and could not indicate if impairment in sustained attention was a predictor of substance use o...
Timing Liu, Alagu Sankareswaran, Gordon Paterson, Shaheen Akhtar et al.
Correct classification of type 1 (T1D) and type 2 diabetes (T2D) is challenging due to overlapping clinical features and the increasingly early onset of T2D, particularly in South Asians. Polygenic risk scores (PRSs) for T1D and T2D have been shown to work relatively well in South Asians, despite be...
Abu Z M Dayem Ullah, Ashitha Joby, Graeme J. Thorn, Lucas M. James et al.
South Asian populations remain underrepresented in cancer genomics, despite elevated risk for certain malignancies and distinct clinical profiles. This gap is especially pronounced for British Bangladeshi and Pakistani communities. We analyse data from 57,416 individuals of Bangladeshi and Pakistani...
Julia Carrasco-Zanini, Maik Pietzner, Mine Koprulu, Martijn Zoodsma et al.
Abstract Human loss-of-function (LoF) variants affecting both copies of a gene (“human knockouts”) provide a unique opportunity to directly study function and clinical impact of genes but are very rare in most populations sequenced to date. Here we study 1,569 British Bangladeshi and -Pakistani adul...
Sam Hodgson, Van-Minh Bui, Siqi Hu, Margherita Bigossi et al.
Abstract / Introductory Paragraph Type 2 diabetes (T2D) is a common and complex metabolic condition with significant heterogeneity within and across ancestries 1–4 . Compared with individuals of European ancestry (EUR), people of south Asian ancestry (SAS) have two to four-fold higher risk of T2D, d...
Yihe Weng, Johann Kruschwitz, Laura M. Rueda‐Delgado, Kathy Ruddy et al.
Abstract Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early adulthood. Previous studies were predominantly cross-sectional or under-powered and could not indicate if impairment in sustained attention was a predictor of substa...