Brandon L. Pierce, Tong Lin, Maria Argos, Kathryn Demanelis et al.
Inherited genetic variation affects local gene expression and DNA methylation in humans. Most expression quantitative trait loci (cis-eQTLs) occur at the same genomic location as a methylation QTL (cis-meQTL), suggesting a common causal variant and shared mechanism. Using DNA and RNA from peripheral...
Kathryn Demanelis, Maria Argos, Tong Lin, Justin Shinkle et al.
BACKGROUND: Arsenic exposure affects [Formula: see text] people worldwide, including [Formula: see text] in Bangladesh. Arsenic exposure increases the risk of cancer and other chronic diseases, and one potential mechanism of arsenic toxicity is epigenetic dysregulation. OBJECTIVE: We assessed associ...
Dayana A. Delgado, Chenan Zhang, Kevin J. Gleason, Kathryn Demanelis et al.
Leukocyte telomere length (LTL) is a heritable trait with two potential sources of heritability (h2): inherited variation in non-telomeric regions (e.g., SNPs that influence telomere maintenance) and variability in the lengths of telomeres in gametes that produce offspring zygotes (i.e., “direct” in...
Kathryn Demanelis, Dayana A. Delgado, Tong Lin, Farzana Jasmine et al.
BACKGROUND: Arsenic exposure increases the risk of several cancers in humans and contributes to genomic instability. Somatic loss of the Y chromosome (LoY) is a potential biomarker of genomic instability and cancer risk. Smoking is associated with LoY, but few other carcinogens have been investigate...
Anthony DiGiovanni, Kathryn Demanelis, Tong Lin, Maria Argos et al.
BACKGROUND: Arsenic exposure affects >100 million people globally and increases risk for chronic diseases. One possible toxicity mechanism is epigenetic modification. Previous epigenome-wide association studies (EWAS) have identified associations between arsenic exposure and CpG-specific DNA methyla...
Dayana A. Delgado, Chenan Zhang, Kathryn Demanelis, Lin Chen et al.
ABSTRACT Leukocyte telomere length (LTL) is a heritable trait with two potential sources of heritability (h 2 ): inherited variation in non-telomeric regions (e.g., SNPs that influence telomere maintenance) and variability in the lengths of telomeres in gametes that produce offspring zygotes (i.e., ...
James L Li, Niyati Jain, Lizeth I. Tamayo, Lin Tong et al.
BACKGROUND: Inorganic arsenic (As) is a carcinogen and >200 million people worldwide are exposed to As through drinking water. Long-term As exposure increases the risk of chronic diseases including cancer and cardiovascular disease. While prior work has identified several genomic regions where DNA m...
Kathryn Demanelis, Maria Argos, Tong Lin, Justin Shinkle et al.
Background: Arsenic exposure affects >200 million people worldwide, including ~56 million in Bangladesh. Arsenic exposure increases the risk of chronic disease, and one potential mechanism of arsenic toxicity is epigenetic dysregulation of DNA methylation.Objective: We assessed associations b...