M. Rafiul Islam, M. Nazmul Hoque, M. Shaminur Rahman, A. S. M. Rubayet Ul Alam et al.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel evolutionary divergent RNA virus, is responsible for the present devastating COVID-19 pandemic. To explore the genomic signatures, we comprehensively analyzed 2,492 complete and/or near-complete genome sequences of SARS-CoV-2 str..
M. Nazmul Hoque, Arif Istiaq, Rebecca Clement, Munawar Sultana et al.
Milk microbiomes significantly influence the pathophysiology of bovine mastitis. To assess the association between microbiome diversity and bovine mastitis, we compared the microbiome of clinical mastitis (CM, n = 14) and healthy (H, n = 7) milk samples through deep whole metagenome sequencing (WMS)...
M. Shaminur Rahman, M. Nazmul Hoque, M. Rafiul Islam, Salma Akter et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the ongoing pandemic of coronavirus disease 2019 (COVID-19), a public health emergency of international concerns declared by the World Health Organization (WHO). An immuno-informatics approach along with comparati...
M. Nazmul Hoque, Arif Istiaq, Rebecca Clement, Keylie M. Gibson et al.
Bovine clinical mastitis (CM) is one of the most prevalent diseases caused by a wide range of resident microbes. The emergence of antimicrobial resistance in CM bacteria is well-known, however the genomic resistance composition (the resistome) at microbiome-level is not well characterized. In this s...
M. Nazmul Hoque, Arif Istiaq, M. Shaminur Rahman, M. Rafiul Islam et al.
The milk of lactating cows presents a complex ecosystem of interconnected microbial communities which can influence the pathophysiology of mastitis. We hypothesized possible dynamic shifts of microbiome composition and genomic features with different pathological conditions of mastitis (Clinical Mas...
M. Nazmul Hoque, Md. Murshed Hasan Sarkar, M. Shaminur Rahman, Shahina Akter et al.
The microbiota of the nasopharyngeal tract (NT) play a role in host immunity against respiratory infectious diseases. However, scant information is available on interactions of SARS-CoV-2 with the nasopharyngeal microbiome. This study characterizes the effects of SARS-CoV-2 infection on human nasoph...
M. Nazmul Hoque, M. Shaminur Rahman, Tofazzal Islam, Munawar Sultana et al.
BACKGROUND: Mastitis pathogenesis involves a wide range of opportunistic and apparently resident microorganims including bacteria, viruses and archaea. In dairy animals, microbes reside in the host, interact with environment and evade the host immune system, providing a potential for host-tropism to...
A. S. M. Rubayet Ul Alam, Ovinu Kibria Islam, Md. Shazid Hasan, Mir Raihanul Islam et al.
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has evolved into eight fundamental clades with four of these clades (G, GH, GR, and GV) globally prevalent in 2020. To explain plausible epistatic effects of the signature co‐occurring mutations of these circulating clades on vira...
M. Nazmul Hoque, M. Shaminur Rahman, Rasel Ahmed, Md. Sabbir Hossain et al.
Abstract The novel coronavirus disease 2019 (COVID-19) is a rapidly emerging and highly transmissible disease caused by the Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2). Understanding the microbiomes associated with the upper respiratory tract infection (URTI), chronic obstructive pu...
M. Rafiul Islam, M. Nazmul Hoque, M. Shaminur Rahman, Joynob Akter Puspo et al.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel evolutionarily divergent RNA virus etiological agent of COVID-19, is responsible for present devastating pandemic respiratory illness. To explore the genomic signatures, we comprehensively analyzed 2,492 complete and/or near-compl...
A. S. M. Rubayet Ul Alam, Ovinu Kibria Islam, Md. Shazid Hasan, Mir Raihanul Islam et al.
ABSTRACT SARS-CoV-2 is evolved into eight fundamental clades where four (G, GH, GR, and GV) are globally prevalent in 2020. How the featured co-occurring mutations of these clades are linked with viral fitness is the main question here and we thus proposed a hypothetical model using in silico approa...
M. Nazmul Hoque, Arif Istiaq, Rebecca Clement, Munawar Sultana et al.
Abstract Milk microbiomes impose a significant influence on the pathophysiology of bovine mastitis. To assess the association, we compared the microbiome of clinical mastitis (CM) and healthy (H) milk samples through whole metagenomic deep sequencing. A total of 483.38 million reads generated from b...
M. Nazmul Hoque, Md. Murshed Hasan Sarkar, M. Shaminur Rahman, Shahina Akter et al.
Background: The SARS-CoV-2 primarily enters into the human body through nasopharyngeal tract (NT) and is the etiological agent of COVID-19. The microbiota of the nasopharyngeal tract may play a role in host immunity against respiratory infectious diseases. However, scant information is available on ...
M. Nazmul Hoque, Arif Istiaq, Rebecca Clement, Keylie M. Gibson et al.
Abstract The bovine clinical mastitis (CM) milk is a large reservoir for diverse groups of resistomes, which play important roles in the pathogenesis of mastitis, but little is known about the concurrence of CM microbiome signature and its associated resistomes. Here we deciphered the total resistan...
Sebastian Pipins, Monika Böhm, Lucie M. Bland, Keith A. Crandall et al.
Abstract Crayfish are an ancient clade of freshwater decapods that play vital and diverse ecological roles in the freshwater systems that they inhabit. One third of assessed crayfish species are threatened with extinction and 87% are highly sensitive to climate change. However, the extent to which t...