Ta‐Chiang Liu, Kelley VanBuskirk, Asad Ali, Paul Kelly et al.
BACKGROUND: A major limitation to understanding the etiopathogenesis of environmental enteric dysfunction (EED) is the lack of a comprehensive, reproducible histologic framework for characterizing the small bowel lesions. We hypothesized that the development of such a system will identify unique his...
Paul Kelly, Kelley VanBuskirk, David Coomes, Samer Mouksassi et al.
BACKGROUND: Environmental enteric dysfunction (EED) is an asymptomatic intestinal disorder associated with growth impairment, delayed neurocognitive development, and impaired oral vaccine responses. OBJECTIVES: We set out to develop and validate a histopathologic scoring system on duodenal biopsies ...
Kelley VanBuskirk, Monica Mweetwa, Tad Kolterman, Shyam S. Raghavan et al.
BACKGROUND: Environmental enteric dysfunction (EED) is characterized by reduced absorptive capacity and barrier function of the small intestine, leading to poor ponderal and linear childhood growth. OBJECTIVES: To further define gene expression patterns that are associated with EED to uncover new pa...
Najeeha Talat Iqbal, Sarah Lawrence, Tahmeed Ahmed, Kanta Chandwe et al.
BACKGROUND: Environmental Enteric Dysfunction (EED) is an acquired disorder of asymptomatic altered gut function, the etiology of which is unknown. EED is postulated to be a major contributor to growth faltering in early childhood in regions where early-life enteropathogenic carriage is prevalent. F...
Zehra Jamil, Kelley VanBuskirk, Monica Mweetwa, Samer Mouksassi et al.
BACKGROUND: Environmental enteric dysfunction (EED) is a precursor of growth faltering in children living in impoverished conditions who are frequently exposed to environmental toxins and enteropathogens, leading to small bowel inflammatory, malabsorptive, and permeability derangements and low-grade...
Mustafa Mahfuz, David Coomes, Marwa Abdalla, Monica Mweetwa et al.
BACKGROUND: Validated biomarkers could catalyze environmental enteric dysfunction (EED) research. OBJECTIVES: Leveraging an EED histology scoring system, this multicountry analysis examined biomarker associations with duodenal histology features among children with EED. We also examined differences ...
Lubaina Ehsan, David Coomes, Paul Kelly, Adam R Greene et al.
BACKGROUND: Environmental enteric dysfunction (EED), a chronic inflammatory condition of the small intestine, is an important driver of childhood malnutrition globally. Quantifying intestinal morphology in EED allows for exploration of its association with functional and disease outcomes. OBJECTIVES...