Helen E. Gruber, Tracy Johnson, Kelly Leslie, Jane A. Ingram et al.
STUDY DESIGN: Work presented here used a small animal model to illustrate the feasibility of autologous disc cell implantation. OBJECTIVES: To develop a small animal model for autologous disc cell implantation. SUMMARY OF THE BACKGROUND DATA: The use of autologous disc cells in the potential treatme...
Claire Palles, Laura Chegwidden, Xinzhong Li, John M. Findlay et al.
BACKGROUND & AIMS: Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subse...
Therese M. Murphy, Maria Ryan, Tom Foster, Chris Kelly et al.
BACKGROUND: Suicidal behaviour is known to aggregate in families. Patients with psychiatric disorders are at higher risk for suicide attempts (SA), however protective and risk genetic variants for suicide appear to be independent of underlying psychiatric disorders. Here we investigate genetic varia...
Robert C. Kauffman, Taufiqur Rahman Bhuiyan, Rie Nakajima, Leslie M. Mayo-Smith et al.
We characterized the acute B cell response in adults with cholera by analyzing the repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) generated from single-cell-sorted plasmablasts. We found that the cholera-induced responses were characterized by high levels...
Therese M. Murphy, Niamh Mullins, Maria Ryan, Tom Foster et al.
Recently, a significant epigenetic component in the pathology of suicide has been realized. Here we investigate candidate functional SNPs in epigenetic-regulatory genes, DNMT1 and DNMT3B, for association with suicide attempt (SA) among patients with co-existing psychiatric illness. In addition, glob...
Kamrul Islam, M. Anowar Hossain, Meagan Kelly, Leslie M. Smith et al.
BACKGROUND: Cholera is an acute voluminous dehydrating diarrheal disease caused by toxigenic strains of Vibrio cholerae O1 and occasionally O139. A growing body of evidence indicates that immune responses targeting the O-specific polysaccharide (OSP) of V. cholerae are involved in mediating protecti...
Richelle C. Charles, Meagan Kelly, Jenny M. Tam, Aklima Akter et al.
Cholera is a severe dehydrating illness of humans caused by Vibrio cholerae . V. cholerae is a highly motile bacterium that has a single flagellum covered in lipopolysaccharide (LPS) displaying O-specific polysaccharide (OSP), and V. cholerae motility correlates with its ability to cause disease. Th...
Motaher Hossain, Kamrul Islam, Meagan Kelly, Leslie M. Smith et al.
BACKGROUND: Antibodies targeting O-specific polysaccharide (OSP) of Vibrio cholerae may protect against cholera; however, little is known about this immune response in infected immunologically naïve humans. METHODOLOGY: We measured serum anti-OSP antibodies in adult North American volunteers experim...
T Hussey, Africa Athanasius, George Mbogo, Brenda Mccoard et al.
Richelle C. Charles, Meagan Kelly, Jenny M. Tam, Aklima Akter et al.
ABSTRACT The mechanism of protection against cholera afforded by previous illness or vaccination is currently unknown. We have recently shown that antibodies targeting O-specific polysaccharide (OSP) of Vibrio cholerae correlate highly with protection against cholera. V. cholerae is highly motile an...
Lina Benson
788 SEER, 82, 3, 2004 Thomas, Raju G. C. (ed.). rugoslaviaUnraveled: Sovereignty, Self-Determination, Intervention. Lexington Books, Lanham, MD, Boulder, CO, New York and Oxford, 2003. xx + 386 pp. Tables. Notes. Index. /65.oo. THIS collection of thirteen essays by twelve authors can be warmly recom...
Hugh J. Willison, Albert J. Lastovica, Melissa Prendergast, Anthony P. Moran et al.
T. K. Cooper, A. I. Traub, Saranne Magennis, N. C. Nevin et al.